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Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2501635122Source: DataRank Database

Engineering a protease-stable, oral single-domain antibody to inhibit IL-23 signaling is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 10 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access10 citations

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Linked data & code

gen pdb

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 3.60)OA: hybridTopics (43)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (25)

C. Davies ORCID,Jing‐Qiong Kang ORCID,Donghong Yan ORCID,Alexis Scherl ORCID,Anne Wong

Live enrichment

PubMed:40434646 PMC:PMC12146698 OpenAlex:https://openalex.org/W4410818205

NIGMS NIH HHS

Grant: P30 GM124165

NIGMS NIH HHS

Grant: P30 GM124169

NIH HHS

Grant: S10 OD021832

FWCI

3.60

Citation Percentile

0.9%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1073/pnas.2501635122

publisherhttps://doi.org/10.1073/pnas.2501635122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2501635122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40434646

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12146698/

Fields of Study

Immunodeficiency and Autoimmune DisordersWhipple's Disease and InterleukinsCytokine Signaling Pathways and InteractionsMedicineEngineeringAnimalsInterleukin-23MiceSingle-Domain AntibodiesHumansSignal TransductionAdministration, OralProtein EngineeringColitisPeptide HydrolasesInflammatory Bowel Diseases

MeSH Terms

Administration, OralAnimalsColitisHumansPeptide HydrolasesProtein EngineeringInflammatory Bowel DiseasesSignal TransductionMiceInterleukin-23Single-Domain Antibodies

Keywords

Inflammatory bowel diseaseAntibodyProteasePharmacologyOral administrationPotencyChemistryImmunologyMedicineDiseaseIn vitroEnzymeBiochemistryInternal medicineProtein engineeringOral Delivery

Sustainable Development Goals

SDG 0: Good health and well-being