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Combining MicroED and native mass spectrometry for structural discovery of enzyme–small molecule complexes

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2503780122Source: DataRank Database

Combining MicroED and native mass spectrometry for structural discovery of enzyme–small molecule complexes is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 4 times.

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Open Access4 citations

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Linked data & code

Serial synchrotron X-ray diffraction datasets of papain microcrystals soaked with E-64 and analogs · European Synchrotron Radiation Facility

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (7 grants)Impact (FWCI 1.28)OA: hybridTopics (36)Linked Datasets (1)DataCite Reuse (1)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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Authors (21)

Cameron W. Flowers,Mengting Liu ORCID,Matthew P. Agdanowski ORCID,Samuel Johnson ORCID,J. Summers ORCID

Live enrichment

PubMed:40720654 PMC:PMC12337315 OpenAlex:https://openalex.org/W4412704091

HHMI

Grant: EPI

HHS | NIH

Grant: GM128867

HHS | NIH

Grant: GM145286

NIGMS NIH HHS

Grant: T32 GM007185

NIGMS NIH HHS

Grant: R35 GM145286

NIGMS NIH HHS

Grant: R35 GM128867

NIGMS NIH HHS

Grant: T32 GM145388

FWCI

1.28

Citation Percentile

0.8%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2503780122

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2503780122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2503780122

journalhttps://doi.org/10.1073/pnas.2503780122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40720654

Fields of Study

Enzyme Structure and FunctionMass Spectrometry Techniques and ApplicationsProtein Structure and DynamicsPapainMass SpectrometrySmall Molecule LibrariesLigandsDrug DiscoveryProtein BindingCysteine Proteinase Inhibitors

MeSH Terms

LigandsPapainProtein BindingMass SpectrometryCysteine Proteinase InhibitorsSmall Molecule LibrariesDrug Discovery

Keywords

ChemistryDrug discoveryPapainNatural productSmall moleculeMass spectrometryCysteine proteaseCombinatorial chemistryLigand (biochemistry)StereochemistryMoleculeCysteineEnzymeChromatographyBiochemistryOrganic chemistryLigandCryoemMicroed

Serial synchrotron X-ray diffraction datasets of papain microcrystals soaked with E-64 and analogs

10.15151/esrf-dc-2206265994European Synchrotron Radiation Facility