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The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2508540122Source: DataRank Database

The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

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Open Access2 citations

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Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 0.77)OA: hybridTopics (35)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Shin‐Yu Lee ORCID,Richard Ågren ORCID,Laís Ceschini Machado ORCID,Jiawei Xing ORCID,Chika Azama ORCID

Live enrichment

PubMed:40758872 PMC:PMC12358879 OpenAlex:https://openalex.org/W4412934523

NIGMS NIH HHS

Grant: R35 GM127070

National Institutes of Health

Grant: 1R35GM127070-01

Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional Regulation

FWCI

0.77

Citation Percentile

0.7%

Citation Trend

2025

2026

hybridLicense: cc-by

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2508540122

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2508540122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2508540122

journalhttps://doi.org/10.1073/pnas.2508540122

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12358879

Fields of Study

Biochemical and Molecular ResearchMetabolism and Genetic DisordersFolate and B Vitamins Research0301 basic medicine03 medical and health sciences

MeSH Terms

Adenylosuccinate LyaseAnimalsBehavior, AnimalBrainBiological EvolutionFemaleHumansEvolution, MolecularAmino Acid SubstitutionMice

Keywords

Purine metabolismEnzymeAsymmetric digital subscriber lineBiologyBiochemistryPurineGeneticsHuman evolutionPurine Biosynthesisadenylosuccinate lyaseEvolution, MolecularMiceAmino Acid SubstitutionBehavior, AnimalAnimalsHumansBrainFemaleBiological SciencesBiological Evolution

Sustainable Development Goals

SDG 0: Clean water and sanitation

The activity and expression of adenylosuccinate lyase were reduced during modern human evolution, affecting brain and behavior

FAIR Checklist

Authors (13)

Funding (2 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)