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Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2508836122Source: DataRank Database

Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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Enrichment:Funding (5 grants)Impact (FWCI 2.09)OA: hybridTopics (37)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Luqun Shen ORCID,Jonathan Indajang ORCID,Neil K. Savalia ORCID,Timothy G. Johnson ORCID,Jiayin Qu ORCID

Live enrichment

PubMed:41264237 PMC:PMC12646510 OpenAlex:https://openalex.org/W4416424398

Simons Foundation Autism Research Initiative

Grant: Pilot Award

HHS | NIH | National Institute of General Medical Sciences

Grant: T32GM007205

HHS | NIH | National Institute of Mental Health

Grant: F30MH129085

HHS | NIH | NIH Office of the Director

Grant: S10OD032251

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: U01NS128660

FWCI

2.09

Citation Percentile

0.9%

Citation Trend

2025

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2508836122

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2508836122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2508836122

journalhttps://doi.org/10.1073/pnas.2508836122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41264237

Fields of Study

Autism Spectrum Disorder ResearchNeurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental DisordersAnimalsHaploinsufficiencyDendritesMiceNAV1.2 Voltage-Gated Sodium ChannelDecision MakingPyramidal CellsAutistic DisorderMaleSignal TransductionAutism Spectrum Disorder

MeSH Terms

Autism Spectrum DisorderAnimalsAutistic DisorderDecision MakingDendritesMaleSignal TransductionPyramidal CellsMiceHaploinsufficiencyNAV1.2 Voltage-Gated Sodium Channel

Keywords

HaploinsufficiencyDendritic spineDendritic cellIn vivoApical dendriteDendritic filopodiaNerve netCalciumDendriteSodium channelPyramidal cellBehavioral Flexibility

Autism-associated Scn2a haploinsufficiency disrupts in vivo dendritic signaling and impairs flexible decision-making

FAIR Checklist

Authors (8)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)