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Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2509312122Source: DataRank Database

Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1 is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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Enrichment:Funding (6 grants)Impact (FWCI 0.77)OA: hybridTopics (38)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

María Esperanza Valdés Sánchez ORCID,Ta I Hung ORCID,Jin Tang ORCID,Wenyan Xu ORCID,Jiekai Yin

Live enrichment

PubMed:41259143 PMC:PMC12663966 OpenAlex:https://openalex.org/W4416385016

HHS | NIH

Grant: R35 GM128854

HHS | NIH

Grant: R35 ES031707

HHS | NIH

Grant: R35 CA274234

HHS | NIH

Grant: R01 CA275712

HHS | NIH

Grant: R01 GM109045

NIH HHS

Grant: S10 OD021724

FWCI

0.77

Citation Percentile

0.7%

Citation Trend

2026

hybridLicense: cc-by-nc-nd

journalhttps://www.pnas.org/doi/pdf/10.1073/pnas.2509312122

publisherhttps://www.pnas.org/doi/pdf/10.1073/pnas.2509312122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2509312122

journalhttps://doi.org/10.1073/pnas.2509312122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41259143

Fields of Study

Mitochondrial Function and PathologyDNA Repair MechanismsDNA and Nucleic Acid ChemistryHumansDNA, MitochondrialDNA AdductsDNA-(Apurinic or Apyrimidinic Site) LyasePhosphoric Diester HydrolasesGlutathioneDNA DamageDNA-Binding ProteinsDNA RepairTranscription FactorsMitochondriaMitochondrial Proteins

MeSH Terms

DNA DamageDNA RepairDNA-Binding ProteinsDNA, MitochondrialGlutathioneHumansMitochondriaPhosphoric Diester HydrolasesTranscription FactorsDNA AdductsMitochondrial ProteinsDNA-(Apurinic or Apyrimidinic Site) Lyase

Keywords

Mitochondrial DNADNA damageDNAMitochondrionDNA repairMutationBase excision repairEndonucleaseGSHTfamPrdx6

Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1

FAIR Checklist

Authors (11)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)