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Fluoride triggers lysis in Streptococcus mutans by inhibition of the Clp protease complex, leading to an unabated competence cascade

Proceedings of the National Academy of Sciences(2025)10.1073/pnas.2511884122Source: DataRank Database

Fluoride triggers lysis in Streptococcus mutans by inhibition of the Clp protease complex, leading to an unabated competence cascade is a research paper published in Proceedings of the National Academy of Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (2 grants)Impact (FWCI 1.46)OA: hybridTopics (35)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Sophie Pickelner ORCID,Faith D. Smith,Lívia Maria Andaló Tenuta ORCID,Randy B Stockbridge ORCID,Aditya Banerjee ORCID

Live enrichment

PubMed:41379997 PMC:PMC12700350 OpenAlex:https://openalex.org/W4417251379

HHS | NIH

Grant: RM1 DE034220

NIH HHS

Grant: S10 OD021619

FWCI

1.46

Citation Percentile

0.8%

Citation Trend

2026

hybridLicense: cc-by-nc-nd

journalhttps://doi.org/10.1073/pnas.2511884122

publisherhttps://doi.org/10.1073/pnas.2511884122

publisherhttps://pnas.org/doi/pdf/10.1073/pnas.2511884122

repositoryhttps://pubmed.ncbi.nlm.nih.gov/41379997

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12700350/

Fields of Study

Oral microbiology and periodontitis researchFluoride Effects and RemovalDental Health and Care UtilizationStreptococcus mutansBacterial ProteinsFluoridesEndopeptidase ClpGene Expression Regulation, BacterialCell WallBacteriocinsBacteriolysisSigma FactorTranscription Factors

MeSH Terms

Bacterial ProteinsBacteriocinsBacteriolysisCell WallFluoridesSigma FactorStreptococcus mutansTranscription FactorsGene Expression Regulation, BacterialEndopeptidase Clp

Keywords

ProteaseLysisFluorideAntimicrobial peptidesAutolysis (biology)EffectorCellAutolysisStress responseClp proteaseCariesSigma Factor

Fluoride triggers lysis in Streptococcus mutans by inhibition of the Clp protease complex, leading to an unabated competence cascade

FAIR Checklist

Authors (5)

Funding (2 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)