Hypermutation in derepressed operons of<i>Escherichia coli</i>K12 is a research paper published in Proceedings of the National Academy of Sciences (1999). On theSindex it has a DataRank of 4.5. It has been cited 73 times, with 63 citing works in its 1-hop citation network.
This article presents evidence that starvation for leucine in anEscherichia coliauxotroph triggers metabolic activities that specifically target theleuoperon for derepression, increased rates of transcription, and mutation. Derepression of theleuoperon was a prerequisite for its activation by the signal nucleotide, guanosine tetraphosphate, which accumulates in response to nutritional stress (the stringent response). A quantitative correlation was established betweenleuBmRNA abundance andleuB−reversion rates. To further demonstrate that derepression increased mutation rates, the chromosomalleuoperon was placed under the control of the inducibletacpromoter. When theleuoperon was induced by isopropyl-d-thiogalactoside, bothleuBmRNA abundance andleuB−reversion rates increased. These investigations suggest that guanosine tetraphosphate may contribute as much as attenuation in regulatingleuoperon expression and that higher rates of mutation are specifically associated with the derepressedleuoperon.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.646
From this paper's citation signal
Citation Network Contribution
3.9
From 60 citing papers with measurable signal
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 14% comes from its base citations and 86% from the citation network (60 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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