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Mutations of the Second Extracellular Loop of the Human Lutropin Receptor Emphasize the Importance of Receptor Activation and De-emphasize the Importance of Receptor Phosphorylation in Agonist-induced Internalization

Journal of Biological Chemistry(2001)10.1074/jbc.m010482200Source: DataRank Database

Mutations of the Second Extracellular Loop of the Human Lutropin Receptor Emphasize the Importance of Receptor Activation and De-emphasize the Importance of Receptor Phosphorylation in Agonist-induced Internalization is a research paper published in Journal of Biological Chemistry (2001). On theSindex it has a DataRank of 1.8. It has been cited 35 times, with 29 citing works in its 1-hop citation network.

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1.8DataRank · unranked

Scored on demand from live citation data

35 citations · 29 citing works in its network
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›Methodology & internals
datarank_citation_only_1hop_v6· scope data_onlyMethodology
Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring
Enrichment:Funding (1 grants)Impact (FWCI 1.45)OA: hybridTopics (25)IDs (PubMed, OpenAlex)

FAIR Checklist

Context only (not used in score)
Findable (1/2)
  • Has DOI
Accessible (0/2)
    Interoperable (0/2)
      Reusable (0/3)

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        DataRank Breakdown

        Base Score 30%Citation Network 70%

        Base Score Contribution

        0.538

        From this paper's citation signal

        Citation Network Contribution

        1.2

        From 27 citing papers with measurable signal

        Learn more about DataRank methodology →

        Top 5 citers driving the network score

        Ranked by each citer's contribution to N(p) — log1p(Cq) divided by its reference count — out of 29 citers.

        1. The Ectodomain of the Luteinizing Hormone Receptor Interacts with Exoloop 2 to Constrain the Transmembrane Region
          Journal of Biological Chemistry200269 citations36 referencesContributes 0.118
        2. Luteinizing Hormone Receptor Signaling
          Encyclopedia of Hormones20032 citations10 referencesContributes 0.110
        3. Dual Role of the Second Extracellular Loop of the Cannabinoid Receptor 1: Ligand Binding and Receptor Localization
          Molecular Pharmacology200970 citations40 referencesContributes 0.107
        4. Evidence That IGF Binding Protein-5 Functions as a Ligand-Independent Transcriptional Regulator in Vascular Smooth Muscle Cells
          Circulation Research200490 citations44 referencesContributes 0.103
        5. Essential role for the second extracellular loop in C5a receptor activation
          Nature Structural & Molecular Biology2005154 citations51 referencesContributes 0.099

        Authors (4)

        Xuebo Liu,Le MinORCID,Mario Ascoli,Shenghua Li
        Live enrichment
        PubMed:11118455OpenAlex:https://openalex.org/W2078432352

        NCI NIH HHS

        Grant: CA-40629

        FWCI

        1.45

        Citation Percentile

        0.8%

        Citation Trend

        2012
        2013
        2014
        2015
        2017
        2019
        2022
        2023
        2024

        hybridLicense: cc-by
        journalhttps://doi.org/10.1074/jbc.m010482200
        publisherhttps://doi.org/10.1074/jbc.m010482200
        repositoryhttps://pubmed.ncbi.nlm.nih.gov/11118455

        Fields of Study

        Receptor Mechanisms and SignalingMass Spectrometry Techniques and ApplicationsNeuropeptides and Animal Physiology

        MeSH Terms

        Cyclic AMPCell LineEndocytosisChorionic GonadotropinHumansMutationPhosphorylationReceptors, LHStructure-Activity Relationship

        Keywords

        InternalizationAgonistMutantReceptorPhosphorylationExtracellularCell biologyAlanine scanningMutagenesisBiologyMolecular biologyBiochemistryGene