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A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP

Journal of Biological Chemistry(2020)10.1074/jbc.ra119.010984Source: DataRank Database

A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 0.650. It has been cited 15 times, with 12 citing works in its 1-hop citation network.

N/A

0.650DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access15 citations · 12 citing works in its network

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Linked data & code

pdb

Data availability

Repositories this paper deposited data in (declared in PubMed).

PDB2QCS

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (8 grants)Impact (FWCI 0.75)OA: hybridTopics (42)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 64%Citation Network 36%

Base Score Contribution

0.416

From this paper's citation signal

Citation Network Contribution

0.234

From 9 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 12 citers.

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The Effect of N6-Methyladenosine Regulators and m6A Reader YTHDC1-Mediated N6-Methyladenosine Modification Is Involved in Oxidative Stress in Human Aortic Dissection
Oxidative Medicine and Cellular Longevity202315 citations72 referencesContributes 0.039
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The Science of The Total Environment202149 citations118 referencesContributes 0.033
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Journal of Molecular Biology202216 citations98 referencesContributes 0.029

Authors (8)

Sahar Aminzai,Tingfei Hu,Amatya Taran,Sheng Li ORCID,Choel Kim ORCID

Live enrichment

PubMed:32506052 PMC:PMC7383375 OpenAlex:https://openalex.org/W3034078709

HHS | National Institutes of Health

Grant: R01-HL132141

HHS | National Institutes of Health

Grant: R01-GM090161

HHS | National Institutes of Health

Grant: 1U19AI117905

HHS | National Institutes of Health

Grant: R01-GM020501

NIGMS NIH HHS

Grant: R01 GM090161

NIAID NIH HHS

Grant: U19 AI117905

NIGMS NIH HHS

Grant: R01 GM020501

NHLBI NIH HHS

Grant: R01 HL132141

FWCI

0.75

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.jbc.org/article/S0021925817501453/pdf

publisherhttp://www.jbc.org/article/S0021925817501453/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925817501453?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925817501453?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.RA119.010984

Fields of Study

Phosphodiesterase function and regulationRenin-Angiotensin System StudiesNitric Oxide and Endothelin EffectsAmino Acid SubstitutionAortic DissectionAortic Aneurysm, ThoracicCell LineCyclic GMP-Dependent Protein Kinase Type IHumansMutation, MissensePhosphorylationProtein MultimerizationProtein Structure, Quaternary

MeSH Terms

Aortic DissectionCell LineHumansPhosphorylationAortic Aneurysm, ThoracicAmino Acid SubstitutionMutation, MissenseProtein Structure, QuaternaryProtein MultimerizationCyclic GMP-Dependent Protein Kinase Type I

Keywords

AutophosphorylationArginineBiologyKinaseBiochemistryEndocrinologyBiophysicsProtein kinase AAmino acidMutagenesisMutantEnzyme structureCardiovascular systemHydrogen/deuterium ExchangeKinase SignalingCyclic Gmp (Cgmp)Protein Kinase G (Pkg)Hydrogen Exchange Mass SpectrometryThoracic Aortic Aneurysm And Dissection (Taad)

Sustainable Development Goals

SDG 0: Good health and well-being

A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (8)

Funding (8 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)