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Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant

Journal of Biological Chemistry(2020)10.1074/jbc.ra119.011955Source: DataRank Database

Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 0.479. It has been cited 11 times, with 5 citing works in its 1-hop citation network.

N/A

0.479DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access11 citations · 5 citing works in its network

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Linked data & code

pdb doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

PDB2LNQ

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 0.68)OA: hybridTopics (62)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 78%Citation Network 22%

Base Score Contribution

0.373

From this paper's citation signal

Citation Network Contribution

0.107

From 5 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 5 citers.

Aggregation Mechanisms and Molecular Structures of Amyloid‐β in Alzheimer's Disease
Chemistry - A European Journal202433 citations115 referencesContributes 0.031
Copper(II) Can Kinetically Trap Arctic and Italian Amyloid-β40 as Toxic Oligomers, Mimicking Cu(II) Binding to Wild-Type Amyloid-β42: Implications for Familial Alzheimer’s Disease
JACS Au202415 citations96 referencesContributes 0.029
Role of copper in central nervous system physiology and pathology
Neural Regeneration Research202426 citations127 referencesContributes 0.026
Metal ion mediated aggregation of Alzheimer's disease peptides and proteins in solutions and at surfaces
Advances in Colloid and Interface Science202320 citations121 referencesContributes 0.025
Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors
Brain and Behavior20251 citations47 referencesContributes 0.015

Authors (12)

Brandon A. Irizarry ORCID,Martine Ziliox,Toru Kawakami ORCID,Tiffany W. Victor ORCID,Feng Xu ORCID

Live enrichment

PubMed:32376688 PMC:PMC7335782 OpenAlex:https://openalex.org/W3022448906

HHS | National Institutes of Health

Grant: NS-094201

National Science Foundation

Grant: EAR-1634415

U.S. Department of Energy

Grant: DE-FG02-94ER14466

NIA NIH HHS

Grant: P50 AG005134

NINDS NIH HHS

Grant: R01 NS094201

National Institutes of Health

Grant: 3P50AG005134-04S3

ALZHEIMERS DISEASE RESEARCH CENTER

FWCI

0.68

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

2025

hybridLicense: cc-by

journalhttp://www.jbc.org/article/S0021925817503178/pdf

publisherhttp://www.jbc.org/article/S0021925817503178/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925817503178?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925817503178?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.RA119.011955

Fields of Study

Alzheimer's disease research and treatmentsDrug Transport and Resistance MechanismsComputational Drug Discovery Methods0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

Protein Conformation, beta-StrandAlzheimer DiseaseAmyloidBrainCopperHumansMolecular ConformationMagnetic Resonance SpectroscopyPeptide FragmentsAmyloid beta-PeptidesCerebral Amyloid AngiopathyMicroscopy, Atomic ForcePlaque, Amyloid

Keywords

Antiparallel (mathematics)Beta sheetAmyloid fibrilFibrilCopperCrystallographyChemistryCollagen fibrilBiophysicsAmyloid (mycology)Materials scienceProtein structureBiochemistryAmyloid βBiologyMedicinePathologyInorganic chemistryOrganic chemistryPhysicsMetal ionsAlzheimer's diseaseAlzheimer diseaseNeurodegenerationVascular diseaseNmr SpectroscopyFourier Transform Ir (Ftir)X-ray Fluorescence Microscopy (Xfm)Amyloid-beta (Ab)Abeta40-iowaAβ40-iowaCerebral Amyloid Angiopathy (Caa,)AmyloidAmyloid beta-PeptidesMagnetic Resonance SpectroscopyMolecular ConformationBrainPlaque, AmyloidMicroscopy, Atomic ForcePeptide FragmentsCerebral Amyloid AngiopathyHumansProtein Conformation, beta-Strand

Sustainable Development Goals

SDG 0: Life in Land

Copper stabilizes antiparallel β-sheet fibrils of the amyloid β40 (Aβ40)-Iowa variant

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (12)

Funding (6 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)