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Knock-in rats with homozygous PSEN1 Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.012542Source: DataRank Database

Knock-in rats with homozygous PSEN1 Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42 and high Aβ43 is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 28 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access28 citations

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Linked data & code

ensembl refseq doi

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (6 grants)Impact (FWCI 3.04)OA: hybridTopics (37)IDs (PubMed, PMC, OpenAlex)Annotations (3)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (2)

Luciano D'adamio ORCID,Marc D. Tambini ORCID

Live enrichment

PubMed:32265300 PMC:PMC7247318 OpenAlex:https://openalex.org/W3014199730

HHS | NIH | National Institute on Aging

Grant: RO1 AG063407

HHS | NIH | National Institute on Aging

Grant: RF1 AG064821

NIA NIH HHS

Grant: R01 AG063407

NIA NIH HHS

Grant: R01 AG052286

National Institutes of Health

Grant: 5R01AG063407-03

Studies of dementia pathogenesis in genetically faithful rat models of Familal Alzheimer disease

National Institutes of Health

Grant: 1RF1AG064821-01

Are mechanisms leading to FAD, SAD and age-associated cognitive decline similar?

FWCI

3.04

Citation Percentile

0.9%

Citation Trend

2020

2021

2022

2023

2024

2026

hybridLicense: cc-by

journalhttp://www.jbc.org/article/S0021925817502756/pdf

publisherhttp://www.jbc.org/article/S0021925817502756/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925817502756?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925817502756?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.RA120.012542

Fields of Study

Computational Drug Discovery MethodsAlzheimer's disease research and treatmentsProtein Structure and Dynamics0301 basic medicine03 medical and health sciences

MeSH Terms

Alzheimer DiseaseAnimalsHomozygotePeptide FragmentsAmyloid beta-PeptidesMice, KnockoutAmino Acid SubstitutionMutation, MissenseMiceRatsPresenilin-1Amyloid Precursor Protein SecretasesRats, TransgenicGene Knock-In Techniques

Keywords

PSEN1MutationPresenilinAmyloid precursor protein secretaseBiologyMedicineGeneticsChemistryMolecular biologyAlzheimer's diseaseAmyloid precursor proteinInternal medicineDiseaseGeneRatAnimal modelAmyloid Precursor Protein (App)Β-amyloid (Aβ)

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being