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CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.014062Source: DataRank Database

CaMKII enhances voltage-gated sodium channel Nav1.6 activity and neuronal excitability is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 1.1. It has been cited 52 times, with 40 citing works in its 1-hop citation network.

N/A

1.1DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access52 citations · 40 citing works in its network

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Linked data & code

refsnp doi

Data availability

Repositories this paper deposited data in (declared in PubMed).

figshare10.6084/m9.figshare.12328031.v1 10.6084/m9.figshare.12328052.v1 10.6084/m9.figshare.12328295.v1 10.6084/m9.figshare.12328478.v1 10.6084/m9.figshare.12330644.v1 10.6084/m9.figshare.12330836.v1

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 1.57)OA: hybridTopics (46)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 56%Citation Network 44%

Base Score Contribution

0.596

From this paper's citation signal

Citation Network Contribution

0.477

From 29 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 40 citers.

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Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation
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Overexpression of NaV1.6 in the rostral ventrolateral medulla in rats mediates stress-induced hypertension via glutamate regulation
Clinical and Experimental Hypertension20225 citations46 referencesContributes 0.039
Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties
European Journal of Medicinal Chemistry20254 citations43 referencesContributes 0.037
Motor training promotes both synaptic and intrinsic plasticity of layer V pyramidal neurons in the primary motor cortex
The Journal of Physiology202213 citations89 referencesContributes 0.030

Authors (5)

Anthony J. Baucum ORCID,Anthony M. Rush,Theodore Cummins ORCID,Andy Hudmon ORCID,Agnes Zybura

Live enrichment

PubMed:32611770 PMC:PMC7450116 OpenAlex:https://openalex.org/W3039444660

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: R01NS053422

HHS | NIH | National Institute on Drug Abuse

Grant: R33DA041876

HHS | NIH | National Institute of Neurological Disorders and Stroke

Grant: U54NS108874

FWCI

1.57

Citation Percentile

0.8%

Citation Trend

2021

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttp://www.jbc.org/article/S0021925817484808/pdf

publisherhttp://www.jbc.org/article/S0021925817484808/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925817484808?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925817484808?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.RA120.014062

Fields of Study

Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmiasAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Cell LineCells, CulturedFemaleHEK293 CellsHumansMaleMice, Inbred C57BLNAV1.6 Voltage-Gated Sodium ChannelNeuronal PlasticityNeuronsPatch-Clamp TechniquesPurkinje Cells

MeSH Terms

AnimalsCell LineCells, CulturedFemaleHumansMaleMice, Inbred C57BLNeuronal PlasticityNeuronsPurkinje CellsPatch-Clamp TechniquesCalcium-Calmodulin-Dependent Protein Kinase Type 2HEK293 CellsNAV1.6 Voltage-Gated Sodium Channel

Keywords

NAV1Sodium channelNav1.5ChemistryBiophysicsNeuroscienceSodiumBiologyPhosphorylationElectrophysiologyCaMKIIPhosphoproteomicsNav1.6Post-translational Modification (Ptm)Ca2+/calmodulin-dependent Protein Kinase Ii (Camkii)