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An autonomous, but INSIG-modulated, role for the sterol sensing domain in mallostery-regulated ERAD of yeast HMG-CoA reductase

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.015910Source: DataRank Database

An autonomous, but INSIG-modulated, role for the sterol sensing domain in mallostery-regulated ERAD of yeast HMG-CoA reductase is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 13 times.

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Open Access13 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)OA: hybridTopics (47)IDs (PubMed, PMC)

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Authors (2)

Randolph Y. Hampton ORCID,Margaret A. Wangeline ORCID

Live enrichment

PubMed:33184059 PMC:PMC7948459

National Institutes of Health

Grant: 5T32GM007240

NIGMS NIH HHS

Grant: T32 GM007240

NIDDK NIH HHS

Grant: R37 DK051996

National Institutes of Health

Grant: 5 R37 DK051996-24

National Institutes of Health

Grant: 5T32GM007240-27

Cell, Molecular and Genetics Training Program

National Institutes of Health

Grant: 2R37DK051996-16

Protein degradation and cholesterol regulation

hybridLicense: cc-by

publisherhttp://www.jbc.org/article/S0021925820000496/pdf

repositoryhttps://escholarship.org/uc/item/2c29h06q

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7948459

Europe_PMChttps://europepmc.org/articles/PMC7948459

Europe_PMChttps://europepmc.org/articles/PMC7948459?pdf=render

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

MeSH Terms

Saccharomyces cerevisiaePolyisoprenyl PhosphatesHydroxymethylglutaryl CoA ReductasesSaccharomyces cerevisiae ProteinsMembrane ProteinsProtein FoldingMutationProteolysisEndoplasmic Reticulum-Associated DegradationProtein Domains

Keywords

UbiquitinHMG-CoA reductaseubiquitin-proteasome systemprotein misfoldingEr Quality ControlCholesterol RegulationEndoplasmic-reticulum-associated Protein Degradation (Erad)Hrd PathwayMallosterySterol Sensing Domain (Ssd)570Biochemistry & Molecular BiologyProtein FoldingBiomedical and clinical sciencesSaccharomyces cerevisiae Proteins1.1 Normal biological development and functioning610Saccharomyces cerevisiaeMedical and Health SciencesPolyisoprenyl PhosphatesProtein DomainsUnderpinning researchendoplasmic-reticulum-associated protein degradationMembrane ProteinsEndoplasmic Reticulum-Associated DegradationBiological SciencesChemical sciencesMutationProteolysisHydroxymethylglutaryl CoA ReductasesBiochemistry and Cell BiologyGeneric health relevancesterol sensing domainResearch Article