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Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

Journal of Biological Chemistry(2020)10.1074/jbc.ra120.016489Source: DataRank Database

Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 18 times.

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Open Access18 citations

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Enrichment:Funding (6 grants)OA: hybridTopics (29)IDs (PubMed, PMC)Annotations (1)

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Authors (6)

Serdal Kırmızıaltın ORCID,Adrienne Chang ORCID,Joshua E. Mayfield ORCID,Yan Zhang ORCID,Kenneth A. Johnson ORCID

Live enrichment

PubMed:33310704 PMC:PMC7948414

Welch Foundation

Grant: F-1604

National Institutes of Health

Grant: R01GM104896

National Institutes of Health

Grant: R01GM114223

National Institutes of Health

Grant: R01AI110577

National Institutes of Health

Grant: R01GM125882

National Institutes of Health

Grant: AD181

hybridLicense: cc-by

publisherhttp://www.jbc.org/article/S0021925820001805/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925820001805?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925820001805?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.RA120.016489

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7948414

Fields of Study

Cations, DivalentHIV InfectionsHIV Reverse TranscriptaseHIV-1HumansKineticsMagnesiumMolecular Dynamics SimulationProtein ConformationThermodynamics

MeSH Terms

HumansHIV-1HIV InfectionsCations, DivalentMagnesiumProtein ConformationKineticsThermodynamicsHIV Reverse TranscriptaseMolecular Dynamics Simulation

Keywords

MagnesiumDNA replicationMetal ionsConformational changeMolecular dynamicsEnzyme CatalysisEnzyme SpecificityInduced FitTransient Kinetics

Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

FAIR Checklist

Authors (6)

Funding (6 grants)

Open Access

Topics

Annotations (Europe PMC)