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Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery

Journal of Biological Chemistry(2020)10.1074/jbc.rev120.013746Source: DataRank Database

Mechanistic cross-talk between DNA/RNA polymerase enzyme kinetics and nucleotide substrate availability in cells: Implications for polymerase inhibitor discovery is a research paper published in Journal of Biological Chemistry (2020). On theSindex it has a DataRank of 0. It has been cited 9 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access9 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 0.14)OA: hybridTopics (40)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (4)

Bijan Mahboubi ORCID,Raymond F. Schinazi ORCID,Baek Kim ORCID,Si’Ana A. Coggins ORCID

Live enrichment

PubMed:32737197 PMC:PMC7521635 OpenAlex:https://openalex.org/W3046598943

NIAID NIH HHS

Grant: R01 AI136581

NIAID NIH HHS

Grant: R01 AI150451

NIMH NIH HHS

Grant: R01 MH116695

FWCI

0.14

Citation Percentile

0.6%

Citation Trend

2021

2022

2025

hybridLicense: cc-by

journalhttp://www.jbc.org/article/S0021925817500058/pdf

publisherhttp://www.jbc.org/article/S0021925817500058/pdf

publisherhttps://api.elsevier.com/content/article/PII:S0021925817500058?httpAccept=text/xml

publisherhttps://api.elsevier.com/content/article/PII:S0021925817500058?httpAccept=text/plain

publisherhttps://syndication.highwire.org/content/doi/10.1074/jbc.REV120.013746

Fields of Study

HIV/AIDS drug development and treatmentCRISPR and Genetic EngineeringDNA and Nucleic Acid ChemistryAnimalsDNA-Directed DNA PolymeraseDNA-Directed RNA PolymerasesDrug DiscoveryEnzyme InhibitorsHumansKineticsNucleotidesSubstrate Specificity

MeSH Terms

AnimalsDNA-Directed DNA PolymeraseEnzyme InhibitorsHumansKineticsNucleotidesDNA-Directed RNA PolymerasesSubstrate SpecificityDrug Discovery

Keywords

PolymeraseBiologyDNA polymeraseEnzymeRNANucleotideBiochemistryDNAIntracellularMolecular biologyCell biologyGeneInhibitorsRNA polymeraseEnzyme kineticsdNTPrNTPenzyme inhibitorNucleoside/nucleotide Metabolism

Sustainable Development Goals

SDG 0: Good health and well-being