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Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington’s disease mouse model

Journal of Enzyme Inhibition and Medicinal Chemistry(2021)10.1080/14756366.2021.1900160Source: DataRank Database

Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington’s disease mouse model is a research paper published in Journal of Enzyme Inhibition and Medicinal Chemistry (2021). On theSindex it has a DataRank of 0. It has been cited 13 times.

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Open Access13 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (12 grants)Impact (FWCI 1.15)OA: goldTopics (70)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (17)

Seung Jae Hyeon,Young‐Hee Kim ORCID,Sungsu Lim ORCID,Min Young Lee ORCID,Jieun Kim ORCID

Live enrichment

PubMed:33771089 PMC:PMC8008885 OpenAlex:https://openalex.org/W3136244628

NIH Grant

Grant: R01NS067283

National Research Foundation of Korea Grant

Grant: NRF-2015M3A9A8030034

National Research Foundation of Korea Grant

Grant: NRF-2016M3C7A1904233

National Research Foundation of Korea Grant

Grant: NRF-2016M3C7A1904344NRF-2020R1H1A2013386

National Research Foundation of Korea Grant

Grant: NRF-2020R1A4A4079870

the National Research Council of Science & Technology (NST) Grant

Grant: CRC-15-04-KIST

Korea Government

Grant: 2E26870

Korea Government

Grant: 2E30180

Korea Government

Grant: 2E30190

National Institutes of Health

Grant: 5R01NS067283-04

Epigenetic Regulation of Heterochromatin Condensation in Huntington's Disease

Ministry of Science, ICT and Future Planning

Korea Institute of Science and Technology

FWCI

1.15

Citation Percentile

0.7%

Citation Trend

2021

2022

2023

2024

2026

goldLicense: cc-by

journalhttps://doi.org/10.1080/14756366.2021.1900160

publisherhttps://doi.org/10.1080/14756366.2021.1900160

publisherhttps://www.tandfonline.com/doi/pdf/10.1080/14756366.2021.1900160

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33771089

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8008885

Fields of Study

Genetic Neurodegenerative DiseasesUbiquitin and proteasome pathwaysEndoplasmic Reticulum Stress and Disease0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsBehavior, AnimalBiosensing TechniquesCell SurvivalCells, CulturedDisease Models, AnimalEnzyme InhibitorsFluorescence Resonance Energy TransferHeterochromatinHistone-Lysine N-MethyltransferaseHuntington DiseaseMiceMice, TransgenicMolecular StructureNeurons

MeSH Terms

AnimalsBehavior, AnimalCell SurvivalCells, CulturedDisease Models, AnimalEnzyme InhibitorsHeterochromatinHuntington DiseaseMice, TransgenicNeuronsHistone-Lysine N-MethyltransferaseBiosensing TechniquesMolecular StructureFluorescence Resonance Energy TransferMice

Keywords

NeuropathologyModulation (music)Cell biologyNeuroscienceFunction (biology)BiologyChemistryDiseasePhysicsMedicineInternal medicineMotor functionHuntington’s DiseaseMedium Spiny NeuronSetdb1Histone H3k9me3-specific TransferaseCell SurvivalMice, TransgenicRM1-950Biosensing TechniquesMiceHeterochromatinFluorescence Resonance Energy TransferAnimalsEnzyme InhibitorsCells, CulturedNeuronsBehavior, AnimalMolecular StructureHistone-Lysine N-MethyltransferaseDisease Models, AnimalHuntington DiseaseTherapeutics. PharmacologyResearch Paper

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Modulation of SETDB1 activity by APQ ameliorates heterochromatin condensation, motor function, and neuropathology in a Huntington’s disease mouse model

FAIR Checklist

Authors (17)

Funding (12 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)