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Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid

The Journal of Experimental Medicine(2020)10.1084/jem.20190730Source: DataRank Database

Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid is a research paper published in The Journal of Experimental Medicine (2020). On theSindex it has a DataRank of 2.6. It has been cited 100 times, with 79 citing works in its 1-hop citation network.

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2.6DataRank · unranked

Scored on demand from live citation data

Open Access100 citations · 79 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (37 grants)OA: hybridTopics (75)IDs (PubMed, PMC)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 27%Citation Network 73%

Base Score Contribution

0.692

From this paper's citation signal

Citation Network Contribution

1.9

From 63 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 79 citers.

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Proceedings of the National Academy of Sciences202214 citations15 referencesContributes 0.181
TGF-β promotes pericyte-myofibroblast transition in subretinal fibrosis through the Smad2/3 and Akt/mTOR pathways
Experimental & Molecular Medicine2022104 citations49 referencesContributes 0.095
Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes)
Arteriosclerosis Thrombosis and Vascular Biology202022 citations34 referencesContributes 0.092
Alterations in the outer retina and choroid in patients after COVID-19 infection
Journal of Infection20231 citations9 referencesContributes 0.077
Identification of a choroid plexus vascular barrier closing during intestinal inflammation
Science2021267 citations75 referencesContributes 0.075

Authors (27)

Christin Hanke‐Gogokhia,Yang Hu ORCID,Rohan Bareja ORCID,Zelda Salfati,Michael Ginsberg ORCID

Live enrichment

PubMed:32196081 PMC:PMC7971135

National Institutes of Health

Grant: EY08538

National Institutes of Health

Grant: GM34107

National Institutes of Health

Grant: EY027038

National Institutes of Health

Grant: 1R21CA224391-01A1

Uncovering the role of m6A in the melanocyte response to ultraviolet light

National Institutes of Health

Grant: 1R01CA194547

National Institutes of Health

Grant: 1U24CA210989

National Institutes of Health

Grant: P50CA211024

National Cancer Institute

Grant: R01CA192176

National Cancer Institute

Grant: P30 CA008748-48

Comunidad Autónoma de Madrid

Grant: 2017-T1/BMD-5247

Agencia Nacional Argentina de Promoción Científica y Tecnológica

Grant: PICT 2014-3687

Starr Foundation

Grant: 2013-028

NYSTEM

Grant: C32596GG

Severo Ochoa Center of Excellence

Grant: SEV-2015-0505

NCI NIH HHS

Grant: R21 CA224391

NIGMS NIH HHS

Grant: R01 GM034107

NCI NIH HHS

Grant: U24 CA210989

NCI NIH HHS

Grant: P30 CA008748

NCI NIH HHS

Grant: R01 CA194547

NEI NIH HHS

Grant: R21 EY027038

NEI NIH HHS

Grant: R01 EY008538

National Institutes of Health

Grant: 2P30CA008748-43

MOUSE GENETICS

National Institutes of Health

Grant: 5R01GM034107-31

Sorting of Plasma Membrane Proteins in Epithelial Cells

National Institutes of Health

Grant: 2R01EY008538-06

RETINA--REVERSED POLARITY IN RPE

National Institutes of Health

Grant: 5R01CA192176-02

Developmental studies to inform clinical stratification and targeting of SHH MB

National Institutes of Health

Grant: 5U24CA210989-04

The joint WCM-NYGC Center for Functional and Clinical Interpretation of Tumor Profiles

National Institutes of Health

Grant: 1R21EY027038-01

Molecular Dissection of Single Foveal Cones

National Institutes of Health

Grant: 1P50CA211024-01A1

Weill Cornell Medicine (WCM) SPORE in Prostate Cancer

National Institutes of Health

Grant: 5R01CA194547-03

The identification and validation of mechanisms and biomarkers for relapse in diffuse large B-cell lymphoma

Fundación Sales

Research to Prevent Blindness

Instituto de Salud Carlos III

Ministerio de Ciencia e Innovación

Pro CNIC Foundation

Calder Research Scholar Award

Dyson Foundation

Pew Latin American Fellowship

hybridLicense: cc-by

publisherhttps://rupress.org/jem/article-pdf/217/6/e20190730/1174063/jem_20190730.pdf

publisherhttps://rupress.org/jem/article-pdf/doi/10.1084/jem.20190730/1766600/jem_20190730.pdf

repositoryhttp://hdl.handle.net/20.500.12105/9328

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/7971135

repositoryhttp://hdl.handle.net/11336/110228

Fields of Study

0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

ChoroidEndotheliumMast CellsEndothelial CellsMelanocytesAnimalsMice, Inbred C57BLInflammationSignal TransductionCell ProliferationOrgan SpecificityTranscription, GeneticGene Expression RegulationHedgehog ProteinsRetinal Pigment EpitheliumImmunomodulationSingle-Cell AnalysisZinc Finger Protein GLI1

Keywords

Hedgehog signaling pathwayTranscription, GeneticINDIAN HEDGEHOGGLI1CHOROIDRetinal Pigment EpitheliumSignal transductionGeneBiochemistryhttps://purl.org/becyt/ford/3.1RetinalPathologyMast CellsMesenchymal stem cellStem cellChoroidal ThicknessLife SciencesAge-Related Macular Degeneration ResearchOrgan SpecificityMelanocytesMedicineSingle-Cell AnalysisCell biologyCancer researchZinc Finger Protein GLI1ArticleRetinaEndothelial stem cellImmunomodulationIn vitroBiochemistry, Genetics and Molecular BiologyHealth SciencesGeneticsAnimalsHedgehog Proteinshttps://purl.org/becyt/ford/3EndotheliumMolecular BiologyBiologyCell ProliferationInflammationENDOTHELIALOcular Manifestations of COVID-19Endothelial CellsMolecular Mechanisms of Retinal Degeneration and RegenerationMice, Inbred C57BLOphthalmologyGene Expression RegulationFOS: Biological sciencesStromal cellGene expressionTranscriptomeHedgehogNeuroscience

Sustainable Development Goals

SDG 3: 3. Good health