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Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention

The Journal of Experimental Medicine(2021)10.1084/jem.20202560Source: DataRank Database

Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention is a research paper published in The Journal of Experimental Medicine (2021). On theSindex it has a DataRank of 0. It has been cited 74 times.

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0DataRank · unranked

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Open Access74 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (16 grants)Impact (FWCI 8.34)OA: greenTopics (64)Linked Datasets (18)DataCite Reuse (18)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

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Findable (2/2)

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Accessible (1/2)

Open Access

Interoperable (2/2)

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Reusable (0/3)

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Authors (24)

Moorthi Ponnusamy ORCID,Olga Prikhodko ORCID,Yuhuan Xie ORCID,Can Zhang ORCID,Phuong Nguyen ORCID

Live enrichment

PubMed:33651103 PMC:PMC7931646 OpenAlex:https://openalex.org/W3135208068

NIA NIH HHS

Grant: P01 AG015379

NIA NIH HHS

Grant: RF1 AG054223

National Institute on Aging

Grant: U01AG048986

BLRD VA

Grant: I01 BX003671

NIA NIH HHS

Grant: R01 AG055784

National Institute on Aging

Grant: R01AG054223

National Institute on Aging

Grant: R01AG055523

National Institute on Aging

Grant: R01AG056061

NIA NIH HHS

Grant: RF1 AG056061

National Institute on Aging

Grant: NS 074501

NINDS NIH HHS

Grant: U01 NS074501

Chen Foundation

Grant: R-86U55A

National Institutes of Health

National Institute of Neurological Disorders and Stroke

National Institute on Aging

Cure Alzheimer’s Fund

FWCI

8.34

Citation Percentile

1.0%

Citation Trend

2017

2021

2022

2023

2024

2025

2026

greenLicense: cc-by-nc-sa

repositoryhttps://escholarship.org/uc/item/06k44177

journalhttps://doi.org/10.1084/jem.20202560

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33651103

repositoryhttp://europepmc.org/pmc/articles/PMC7931646

Fields of Study

Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsAlzheimer DiseaseAmyloid Precursor Protein SecretasesAmyloid beta-PeptidesAnimalsCell Line, TumorDisease Models, AnimalDose-Response Relationship, DrugDrug Evaluation, PreclinicalFemaleHumansMacaca fascicularisMaleMiceMice, Inbred C57BLMice, TransgenicNeuroblastomaPeptide FragmentsPhenethylaminesPyridazinesRatsRats, Sprague-DawleySignal TransductionTreatment Outcome

MeSH Terms

Alzheimer DiseaseAnimalsDisease Models, AnimalDose-Response Relationship, DrugDrug Evaluation, PreclinicalFemaleHumansMacaca fascicularisMaleMice, Inbred C57BLMice, TransgenicNeuroblastomaPeptide FragmentsPhenethylaminesPyridazinesSignal TransductionAmyloid beta-PeptidesTreatment OutcomeRats, Sprague-DawleyCell Line, TumorMiceRatsAmyloid Precursor Protein Secretases

Keywords

Gamma secretaseAmyloid precursor protein secretaseTransgenePharmacologyMedicineGenetically modified mouseDiseaseAlzheimer's diseaseAdverse effectBiologyInternal medicineCell biologyAmyloid precursor proteinGeneBiochemistry

Sustainable Development Goals

SDG 0: Good health and well-being

Additional file 1 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 1 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 2 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 2 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 4 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 6 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 3 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 3 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

10.6084/m9.figshare.24144129.v1figshare

Additional file 6 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

10.6084/m9.figshare.24144138.v1figshare

Additional file 4 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

10.6084/m9.figshare.24144132figshare

Additional file 8 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 8 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 5 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 7 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

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Additional file 7 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

10.6084/m9.figshare.24144141figshare

Additional file 9 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

10.6084/m9.figshare.24144147figshare

Additional file 5 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

10.6084/m9.figshare.24144135figshare

Additional file 9 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

10.6084/m9.figshare.24144147.v1figshare

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Preclinical validation of a potent γ-secretase modulator for Alzheimer’s disease prevention

FAIR Checklist

Authors (24)

Funding (16 grants)

Impact

Open Access

Topics

Linked Datasets (18)

Annotations (Europe PMC)

Related Papers (7)