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The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions

Journal of Crohn s and Colitis(2020)10.1093/ecco-jcc/jjaa182Source: DataRank Database

The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions is a research paper published in Journal of Crohn s and Colitis (2020). On theSindex it has a DataRank of 0. It has been cited 79 times.

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Open Access79 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)Impact (FWCI 2.32)OA: greenTopics (105)Linked Datasets (4)DataCite Reuse (4)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (2/2)

Has DOI
Indexed in repositories

Accessible (1/2)

Open Access

Interoperable (2/2)

DataCite relations
Linked datasets

Reusable (0/3)

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Authors (10)

Anica Sayoc-Becerra ORCID,Christ Ordookhanian ORCID,Vinicius Canale ORCID,Alina N. Santos ORCID,Stephanie King

Live enrichment

PubMed:32909045 PMC:PMC7944512 OpenAlex:https://openalex.org/W3085001985

Swiss National Science Foundation

Grant: P300PB_177932

NIH

Grant: R21AI137830

NIH

Grant: 2R01DK091281

NIH

Grant: 1R01AI153314

ASPIRE-Pfizer 2017 IBD Research Award

Grant: W1227049

Pfizer Global Medical Grants 2020 Research Award

Grant: 59444033

Swiss National Science Foundation

Grant: 177932

Consequences of Epithelial Barrier Defects on Intestinal Macrophage Function

NIDDK NIH HHS

Grant: R01 DK091281

NIAID NIH HHS

Grant: R01 AI153314

National Institutes of Health

Grant: 1R01AI153314-01

Tyrosine Phosphatase Regulation of Mucosal Macrophage-Epithelial Cell Cross-talk

Wellcome Trust

Grant: unidentified

unidentified

National Institutes of Health

Grant: 5R21AI137830-02

Human resistin regulation of inflammation and endotoxic shock

National Institutes of Health

Grant: 5R01DK091281-07

A novel role for PTPN2 in intestinal epithelial barrier regulation

UC Riverside School of Medicine Medical Student Externship Scholarship

FWCI

2.32

Citation Percentile

0.9%

Influential Citations

Citation Trend

2020

2021

2022

2023

2024

2025

2026

greenLicense: other-oa

repositoryhttps://www.zora.uzh.ch/id/eprint/190593/1/190593_Spalinger_Sayoc-Becerra_JCC_final_version.pdf

GREENhttps://www.zora.uzh.ch/id/eprint/190593/1/190593_Spalinger_Sayoc-Becerra_JCC_final_version.pdf

repositoryhttps://www.zora.uzh.ch/id/eprint/190593/1/190593_Spalinger_Sayoc-Becerra_JCC_final_version.pdf

publisherhttp://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjaa182/33859897/jjaa182.pdf

publisherhttp://academic.oup.com/ecco-jcc/article-pdf/15/3/471/36463190/jjaa182.pdf

Fields of Study

Protein Tyrosine PhosphatasesInflammatory Bowel DiseaseCeliac Disease Research and ManagementMedicineBiology0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsCell CommunicationCoculture TechniquesDisease Models, AnimalEpithelial CellsHumansInterleukin-6InterleukinsIntestinal MucosaJanus Kinase InhibitorsMacrophagesMice, KnockoutPiperidinesProtein Tyrosine Phosphatase, Non-Receptor Type 2PyrimidinesSTAT3 Transcription FactorSignal TransductionInterleukin-22Mice

MeSH Terms

Janus Kinase InhibitorsInterleukin-22AnimalsCell CommunicationDisease Models, AnimalEpithelial CellsHumansInterleukinsIntestinal MucosaMacrophagesPiperidinesPyrimidinesSignal TransductionInterleukin-6Mice, KnockoutCoculture TechniquesSTAT3 Transcription FactorMiceProtein Tyrosine Phosphatase, Non-Receptor Type 2

Keywords

TofacitinibBarrier functionMedicineJanus kinaseIntestinal epitheliumColitisInflammatory bowel diseaseIntestinal mucosaTight junctionSTAT proteinImmunologyCell biologyCancer researchEpitheliumSTAT3Signal transductionCytokineInternal medicineBiologyPathologyRheumatoid arthritisMacrophagePermeabilityEpithelial cellsJAK-STATIbdTcptpSTAT3 Transcription FactorKnockoutClinical Sciences610 Medicine & healthCrohn's DiseaseCell CommunicationInterleukin-22Autoimmune DiseaseOral and gastrointestinalMicePiperidines2.1 Biological and endogenous factorsAnimalsHumansJanus Kinase InhibitorsAetiology610 Medicine & healthNon-Receptor Type 2Mice, KnockoutProtein Tyrosine Phosphatase, Non-Receptor Type 2Gastroenterology & HepatologyAnimalInterleukin-6InterleukinsMacrophagesCoculture TechniquesDisease Models, Animal10219 Clinic for Gastroenterology and HepatologyPyrimidinesDisease ModelsProtein Tyrosine PhosphataseDigestive Diseases

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Clean water and sanitation

Additional file 1 of Serinc2 deficiency causes susceptibility to sepsis-associated acute lung injury

10.6084/m9.figshare.20267423.v1figshare

Additional file 1 of Serinc2 deficiency causes susceptibility to sepsis-associated acute lung injury

10.6084/m9.figshare.20267423figshare

Additional file 2 of Serinc2 deficiency causes susceptibility to sepsis-associated acute lung injury

10.6084/m9.figshare.20267426.v1figshare

Additional file 2 of Serinc2 deficiency causes susceptibility to sepsis-associated acute lung injury

10.6084/m9.figshare.20267426figshare

The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions

FAIR Checklist

Authors (10)

Funding (14 grants)

Impact

Open Access

Topics

Linked Datasets (4)

Annotations (Europe PMC)