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Cardiac β2 adrenergic receptor deletion drives calmodulin kinase II upregulation to induce connective tissue growth factor in cardiac fibrosis and diastolic dysfunction

Function(2025)10.1093/function/zqaf036Source: DataRank Database

Cardiac β2 adrenergic receptor deletion drives calmodulin kinase II upregulation to induce connective tissue growth factor in cardiac fibrosis and diastolic dysfunction is a research paper published in Function (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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Enrichment:Funding (12 grants)Impact (FWCI 0.98)OA: goldTopics (53)IDs (PubMed, PMC, OpenAlex)Annotations (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (5)

Meimi Zhao,Luqi Zhao ORCID,Mingfu Wu ORCID,Yang K. Xiang ORCID,Chaoqun Zhu ORCID

Live enrichment

PubMed:40796320 PMC:PMC12448417 OpenAlex:https://openalex.org/W4413112769

National Institutes of Health

Grant: R01-HL147263

National Institutes of Health

Grant: R01-HL162825

National Institutes of Health

Grant: 2R01HL121700-06A1

National Institutes of Health

Grant: 1R01HL172834-01

VA Merit

Grant: IK6BX005753

VA Merit

Grant: I01BX005100

American Heart Association

Grant: 24TPA1303770

American Heart Association

Grant: 25EIA1422015

NHLBI NIH HHS

Grant: R01 HL172834

NHLBI NIH HHS

Grant: R01 HL162825

NHLBI NIH HHS

Grant: R01 HL147263

NHLBI NIH HHS

Grant: R01 HL121700

FWCI

0.98

Citation Percentile

0.8%

Citation Trend

2026

goldLicense: cc-by

journalhttps://doi.org/10.1093/function/zqaf036

publisherhttps://doi.org/10.1093/function/zqaf036

publisherhttps://journals.physiology.org/doi/full/10.1093/function/zqaf036

publisherhttps://journals.physiology.org/doi/pdf/10.1093/function/zqaf036

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40796320

Fields of Study

Connective tissue disorders researchCardiac Fibrosis and RemodelingPulmonary Hypertension Research and TreatmentsAnimalsConnective Tissue Growth FactorCalcium-Calmodulin-Dependent Protein Kinase Type 2MiceFibrosisReceptors, Adrenergic, beta-2Myocytes, CardiacUp-RegulationMice, KnockoutNifedipineMyocardiumCalcium SignalingDiastoleMale

MeSH Terms

AnimalsDiastoleFibrosisMaleMyocardiumNifedipineUp-RegulationReceptors, Adrenergic, beta-2Mice, KnockoutCalcium SignalingMyocytes, CardiacMiceCalcium-Calmodulin-Dependent Protein Kinase Type 2Connective Tissue Growth Factor

Keywords

Downregulation and upregulationFibrosisCardiac fibrosisMyocardial fibrosisDiastoleAdrenergic receptorCardiac dysfunctionMedicineInternal medicineAdrenergicCardiologyEndocrinologyReceptorBiologyHeart failureGeneBlood pressureGeneticsConnective tissue growth factorCalmodulin-dependent Protein Kinase IiΒ2-adrenergic ReceptorL-type Calcium Channel Blocker