Estimates of the Rate and Distribution of Fitness Effects of Spontaneous Mutation in <i>Saccharomyces cerevisiae</i> is a research paper published in Genetics (2001). On theSindex it has a DataRank of 7.8. It has been cited 175 times, with 164 citing works in its 1-hop citation network.
Abstract The per-genome, per-generation rate of spontaneous mutation affecting fitness (U) and the mean fitness cost per mutation (s) are important parameters in evolutionary genetics, but have been estimated for few species. We estimated U and sh (the heterozygous effect of mutations) for two diploid yeast strains differing only in the DNA mismatch-repair deficiency used to elevate the mutation rate in one (mutator) strain. Mutations were allowed to accumulate in 50 replicate lines of each strain, during 36 transfers of randomly chosen single colonies (∼600 generations). Among wild-type lines, fitnesses were bimodal, with one mode showing no change in mean fitness. The other mode showed a mean 29.6% fitness decline and the petite phenotype, usually caused by partial deletion of the mitochondrial genome. Excluding petites, maximum-likelihood estimates adjusted for the effect of selection were U = 9.5 × 10-5 and sh = 0.217 for the wild type. Among the mutator lines, the best fit was obtained with 0.005 ≤ U ≤ 0.94 and 0.049 ≥ sh ≥ 0.0003. Like other recently tested model organisms, wild-type yeast have low mutation rates, with high mean fitness costs per mutation. Inactivation of mismatch repair increases the frequency of slightly deleterious mutations by approximately two orders of magnitude.
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Base Score Contribution
0.776
From this paper's citation signal
Citation Network Contribution
7.0
From 136 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 10% comes from its base citations and 90% from the citation network (136 citing papers contributed measurable signal).
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