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Allele-specific variation atAPOEincreases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction

Human Molecular Genetics(2021)10.1093/hmg/ddab096Source: DataRank Database

Allele-specific variation atAPOEincreases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction is a research paper published in Human Molecular Genetics (2021). On theSindex it has a DataRank of 1.2. It has been cited 41 times, with 35 citing works in its 1-hop citation network.

N/A

1.2DataRank · unranked

Scored on demand from live citation data

Open Access41 citations · 35 citing works in its network

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DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (70 grants)Impact (FWCI 4.00)OA: greenTopics (55)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 47%Citation Network 53%

Base Score Contribution

0.561

From this paper's citation signal

Citation Network Contribution

0.641

From 25 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 35 citers.

Genome‐Wide Association Study of NAFLD Using Electronic Health Records
Hepatology Communications2021100 citations54 referencesContributes 0.085
Contribution of a genetic risk score to ethnic differences in fatty liver disease
Liver International202245 citations53 referencesContributes 0.072
Global Epidemiological Impact of PNPLA3 I148M on Liver Disease
Liver International202449 citations67 referencesContributes 0.058
Melatonin Alleviates PM2.5‐Induced Hepatic Steatosis and Metabolic‐Associated Fatty Liver Disease in ApoE-/- Mice
Oxidative Medicine and Cellular Longevity202219 citations60 referencesContributes 0.050
Shared Genetic Links Between Nonalcoholic Fatty Liver Disease and Coronary Artery Disease
Global Heart20244 citations39 referencesContributes 0.041

Authors (36)

Bratati Kahali ORCID,Annapurna Kuppa ORCID,Yanhua Chen ORCID,Xiaomeng Du,Mary F. Feitosa ORCID

Live enrichment

PubMed:33856023 OpenAlex:https://openalex.org/W3154152510

National Institutes of Health

Grant: RO1 DK107904

National Institutes of Health

Grant: R01 DK106621

National Institutes of Health

Grant: P30 DK72488

National Institutes of Health

Grant: U01 HL137181

National Institutes of Health

Grant: U01 HL84756

National Institutes of Health

Grant: U01 HL072515

National Institutes of Health

Grant: HL087660

National Institutes of Health

Grant: HL085571

National Institutes of Health

Grant: HHSN271201200022C

National Institutes of Health

Grant: N01-AG-1-2100

American Diabetes Association Mentor-Based Postdoctoral Fellowship Program

Grant: 7-07-MN-08

National Institute on Aging

Grant: RC2 AG036495

National Institute on Aging

Grant: NIA U01AG009740

U.S. Department of Health and Human Services

Grant: HHSN271201100004C

U.S. Department of Health and Human Services

Grant: HHSN268201100004C

U.S. Department of Health and Human Services

Grant: HHSN268201100003C

U.S. Department of Health and Human Services

Grant: HHSN268201100002C

U.S. Department of Health and Human Services

Grant: HHSN268201100001C

U.S. Department of Health and Human Services

Grant: HHSN268201100046C

Diabetes Research Center

Grant: DK063491

National Center for Advancing Translational Sciences

Grant: UL1TR001881

National Heart, Lung, and Blood Institute

Grant: UL1-TR-001420

National Heart, Lung, and Blood Institute

Grant: UL1-TR-001079

National Heart, Lung, and Blood Institute

Grant: UL1-TR-000040

National Heart, Lung, and Blood Institute

Grant: N01-HC-95169

National Heart, Lung, and Blood Institute

Grant: N01-HC-95168

National Heart, Lung, and Blood Institute

Grant: N01-HC-95167

National Heart, Lung, and Blood Institute

Grant: N01-HC-95166

National Heart, Lung, and Blood Institute

Grant: N01-HC-95165

National Heart, Lung, and Blood Institute

Grant: 75N92020D00007

National Heart, Lung, and Blood Institute

Grant: N01-HC-95164

National Heart, Lung, and Blood Institute

Grant: 75N92020D00004

National Heart, Lung, and Blood Institute

Grant: N01-HC-95163

National Heart, Lung, and Blood Institute

Grant: 75N92020D00006

National Heart, Lung, and Blood Institute

Grant: N01-HC-95162

National Heart, Lung, and Blood Institute

Grant: 75N92020D00003

National Heart, Lung, and Blood Institute

Grant: N01-HC-95161

National Heart, Lung, and Blood Institute

Grant: 75N92020D00002

National Heart, Lung, and Blood Institute

Grant: N01-HC-95160

National Heart, Lung, and Blood Institute

Grant: 75N92020D00005

National Heart, Lung, and Blood Institute

Grant: N01-HC-95159

National Heart, Lung, and Blood Institute

Grant: HHSN268201500003I

National Heart, Lung, and Blood Institute

Grant: 75N92020D00001

National Heart, Lung, and Blood Institute

Grant: R01 HL061210

National Heart, Lung, and Blood Institute

Grant: R01 HL060894

National Heart, Lung, and Blood Institute

Grant: R01 HL060919

National Heart, Lung, and Blood Institute

Grant: R01 HL061019

National Heart, Lung, and Blood Institute

Grant: R01 HL060944

National Heart, Lung, and Blood Institute

Grant: HL100245

National Heart, Lung, and Blood Institute

Grant: N02-HL64278

National Heart, Lung, and Blood Institute

Grant: HHSN268201500001I

National Heart, Lung, and Blood Institute

Grant: N01-HC-25195

University of Mississippi Medical Center

Grant: HHSN268201800012I

University of Mississippi Medical Center

Grant: HHSN268201800011I

University of Mississippi Medical Center

Grant: HHSN268201800010I

Mississippi State Department of Health

Grant: HHSN268201800015I

Jackson State University

Grant: HHSN268201800013I

UNC Nutrition Obesity Research Center

Grant: P30 DK072488

NIDDK

Grant: DK085175

National Institute of Diabetes and Digestive and Kidney Diseases

Grant: R01 DK089256

National Heart, Lung, and Blood Institute

Grant: R01 HL117078

National Heart, Lung, and Blood Institute

Grant: R01 HL08770003

NIDDK NIH HHS

Grant: R01 DK085175

NIDDK NIH HHS

Grant: P30 DK056341

NIA NIH HHS

Grant: U01 AG009740

NIA NIH HHS

Grant: RC4 AG039029

NHLBI NIH HHS

Grant: U01 HL084756

NIDDK NIH HHS

Grant: P30 DK063491

NHLBI NIH HHS

Grant: N01 HC025195

NIDDK NIH HHS

Grant: R01 DK107904

FWCI

4.00

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

greenLicense: https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model

repositoryhttps://mpra.ub.uni-muenchen.de/82793/1/MPRA_paper_78871.pdf

publisherhttp://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddab096/37938381/ddab096.pdf

publisherhttp://academic.oup.com/hmg/article-pdf/30/15/1443/38889202/ddab096.pdf

journalhttps://doi.org/10.1093/hmg/ddab096

Fields of Study

Liver Disease Diagnosis and TreatmentGenetic Associations and EpidemiologyFolate and B Vitamins ResearchAlanine TransaminaseAllelesAlzheimer DiseaseApolipoproteins EDatabases, GeneticExomeGene FrequencyGenome-Wide Association StudyHumansLiverLiver CirrhosisMyocardial InfarctionNon-alcoholic Fatty Liver DiseaseObesityPhenotypePolymorphism, Single NucleotidePrognosisRisk FactorsTriglycerides

MeSH Terms

Alanine TransaminaseAllelesAlzheimer DiseaseApolipoproteins EGene FrequencyHumansLiverLiver CirrhosisMyocardial InfarctionObesityPhenotypePrognosisRisk FactorsTriglyceridesPolymorphism, Single NucleotideDatabases, GeneticGenome-Wide Association StudyExomeNon-alcoholic Fatty Liver Disease

Keywords

Nonalcoholic fatty liver diseaseApolipoprotein EFatty liverSteatosisChronic liver diseaseInternal medicineBiologyInsulin resistanceCirrhosisPopulationMedicineDiseaseObesityEnvironmental health

Sustainable Development Goals

SDG 0: Good health and well-being