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Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Human Molecular Genetics(2022)10.1093/hmg/ddac050Source: DataRank Database

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes is a research paper published in Human Molecular Genetics (2022). On theSindex it has a DataRank of 0. It has been cited 128 times.

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Enrichment:Funding (57 grants)Impact (FWCI 18.76)OA: hybridTopics (92)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

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Authors (73)

Gunn-Helen Moen ORCID,Maria Carolina Borges ORCID,Teresa Ferreira ORCID,James P. Cook ORCID,Catherine Allard ORCID

Live enrichment

PubMed:35220425 PMC:PMC9523562 OpenAlex:https://openalex.org/W4214500137

UK Medical Research Council and Wellcome

Grant: 217065/Z/19/

Wellcome

Grant: WT088806

Swedish Research Council

Grant: 521-2010-3490

Swedish Research Council

Grant: 2010-5983

Swedish Research Council

Grant: 2012-5538

Swedish Research Council

Grant: 2014-6395

UK Economic and Social Science Research Council

Grant: MR/N024397/1

Born in Bradford 2nd Wave

British Heart Foundation

Grant: CS/16/4/32482

Academy of Finland

Grant: 263401

Using the unique knowledge of the genetic architecture of Finland to identify the genetic variants which explain the inherited risk of of diabetes

Academy of Finland

Grant: 267882

Using the unique knowledge of the genetic architecture of Finland to identify the genetic variants which explain the inherited risk of of diabetes

Academy of Finland

Grant: 312063

Center of Excellence in Complex Disease Genetics-from Discovery to Precision Medicine / Consortium: CoECDG

Academy of Finland

Grant: 336822

Center of Excellence in Complex Disease Genetics-from Discovery to Precision Medicine

Academy of Finland

Grant: 312072

Center of Excellence in Complex Disease Genetics-from Discovery to Precision Medicine / Consortium: CoECDG

Academy of Finland

Grant: 336826

Center of Excellence in Complex Disease Genetics-from Discovery to Precision Medicine

European Research Council

Grant: 669545

Effects of maternal gestational adiposity on fetal development and perinatal, postnatal and next generation health.

NIH HHS

Grant: UH3 OD023286

Novo Nordisk Fonden

Grant: NNF20OC0063930

European Research Council

Grant: 269045

General and targeted approaches to unravel the molecular causes of type 2 diabetes

British Heart Foundation

Grant: AA/18/7/34219

Medical Research Council

Grant: MC_UU_00011/6

Reproductive and cardio-metabolic health

National Institute for Health Research (NIHR)

Grant: NF-SI-0616-10102

NICHD NIH HHS

Grant: R01 HD034568

Medical Research Council

Grant: MR/R010676/1

Novo Nordisk Fonden

Grant: NNF19OC0057393

British Heart Foundation

Grant: CH/F/20/90003

Medical Research Council

Grant: MR/S03658X/1

HDHL: A precision nutri-epigenetic approach to tackle the mother-to-child transmission of impaired glucose metabolism

Novo Nordisk Fonden

Grant: NNF21OC0070222

Dutch Research Council (NWO)

Grant: 047.016.009

Development of algorithms and software for high-performance computing in genetic analysis of complex human traits

Medical Research Council

Grant: MR/P014054/1

Understanding the role of fatty acids in the aetiology of cardiovascular disease using novel causal inference methods

Canadian Institutes of Health Research

Grant: unidentified

unidentified

National Institutes of Health

Grant: 4UH3OD023286-03

Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methods

UK Research and Innovation

Grant: G0800441

Does abnormal one-carbon metabolism or hyperglycaemia in utero cause epigenetic change and fetal programming of cardiome

Netherlands Organisation for Scientific Research (NWO)

Grant: 047.017.043

Dissecting genetic complexity of Alzheimer's disease and cognitive function

European Commission

Grant: 874739

Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases

The Research Council of Norway

Grant: 287198

Why does low birth weight increase the risk of diabetes and other cardiometabolic diseases? A study of genetic factors in HUNT

Wellcome Trust

Grant: 217065

The Avon Longitudinal Study of Parents and Children (ALSPAC): A multi-generation, longitudinal resource focusing on life course health and well-being.

European Commission

Grant: 810645

the Center for Genomics, Evolution and Medicine

Wellcome Trust

Grant: 104150

Using genetics to understand how the maternal intrauterine environment influences fetal growth.

European Commission

Grant: 824989

A federated FAIR platform enabling large-scale analysis of high-value cohort data connecting Europe and Canada in personalized health

Research Council of Finland

Grant: 285547

Northern Finland Birth Cohort (NFBC) Programme: Exposomic, Genomic and Epigenomic Approach to Prediction of Metabolic and Cardiorespiratory function and Ill-Health (EGEA)

European Commission

Grant: 848158

Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

French National Research Agency (ANR)

Grant: ANR-18-IBHU-0001

Wellcome Trust

Grant: 220390

Using genetics to understand causal mechanisms underlying adverse outcomes of obese pregnancies

European Commission

Grant: 101017802

Combining optoacoustic imaging phenotypes and multi-omics to advance diabetes healthcare

European Commission

Grant: 733206

Early-life stressors and LifeCycle health

European Commission

Grant: 633595

Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging

French National Research Agency (ANR)

Grant: ANR-10-LABX-0046

French National Research Agency (ANR)

Grant: ANR-16-CE17-0017

The impact of gestational diabetes mellitus (GDM) upon the epigenetics of mother and newborn infant and long-term risk of type 2 diabetes

Wellcome Trust

Grant: 088806

Genome-wide association study of maternal pregnancy phenotypes and later-life maternal and offspring vascular and metabolic phenotypes.

Wellcome Trust

Grant: 101597

The Born in Bradford (BiB) Study an international biomedical resource for exploring genetic and early life determinants of health and development in a deprived multi-ethnic population.

European Commission

Grant: 600914

MOSAIC - MOdels and Simulation techniques for discovering diAbetes Influence faCtors

European Commission

Grant: 640887

Low Temperature Ceramics Applications

National Institutes of Health

Grant: 3R01HD034568-17S2

Early vitamin D status and supplement use and later body composition and bone health

Medical Research Council

National Institute for Health Research (NIHR)

Wellcome Trust

FWCI

18.76

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

hybridLicense: cc-by

journalhttps://doi.org/10.1093/hmg/ddac050

publisherhttps://doi.org/10.1093/hmg/ddac050

publisherhttps://academic.oup.com/hmg/advance-article-pdf/doi/10.1093/hmg/ddac050/43056609/ddac050.pdf

publisherhttps://academic.oup.com/hmg/article-pdf/31/19/3377/46199427/ddac050.pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35220425

Fields of Study

Gestational Diabetes Research and ManagementEpigenetics and DNA MethylationGenetic Associations and Epidemiology0301 basic medicine0303 health sciences03 medical and health sciencesDiabetes Mellitus, Type 2Diabetes, GestationalFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGlucoseHumansPolymorphism, Single NucleotidePregnancy

MeSH Terms

Diabetes Mellitus, Type 2FemaleGlucoseHumansPregnancyDiabetes, GestationalGenetic Predisposition to DiseasePolymorphism, Single NucleotideGenome-Wide Association Study

Keywords

Gestational diabetesGenome-wide association studyBiologyMendelian randomizationType 2 diabetesTCF7L2Genetic associationGeneticsBioinformaticsPregnancyDiabetes mellitusEndocrinologyGenotypeSingle-nucleotide polymorphismGestationGeneGenetic variantsFOS: Computer and information sciencesprotein p16Birth-WeightDiabetes Mellitus, Type 2 - genetics3121tcf7l2 geneglucoseAssociation Studies ArticleLociVariantsObstetrics and GynecologyLife SciencesGestational Diabetes Mellitus[SDV] Life Sciences [q-bio]MedicineFemalebody mass index procedureVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774Diabetes, Gestational - geneticsRiskcdkn2b genediabetes mellitus type 22716 Genetics (clinical)VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714AnnotationEpigenetic Modifications and Their Functional Implications610Polymorphism, Single Nucleotide1311 GeneticsInfluencing Glycemic TraitsSDG 3 - Good Health and Well-beingBiochemistry, Genetics and Molecular BiologyHealth Sciences1312 Molecular BiologyHumansWomenGenetic Predisposition to DiseasegenomeMolecular BiologyLd Score RegressionDiabetes Mellitus, Type 2 - epidemiologyPolymorphism, Single Nucleotide - geneticsVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Gynekologi og obstetrikk: 756Genomic Studies and Association AnalysesDiabetes, GestationalDiabetes Mellitus, Type 2genes p16HyperglycemiaFOS: Biological sciencesImpact of Gestational Diabetes Mellitus on PregnancyVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk molekylærbiologi: 711

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being