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Alzheimer’s disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity

Human Molecular Genetics(2024)10.1093/hmg/ddae115Source: DataRank Database

Alzheimer’s disease risk gene CD2AP is a dose-sensitive determinant of synaptic structure and plasticity is a research paper published in Human Molecular Genetics (2024). On theSindex it has a DataRank of 0. It has been cited 10 times.

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0DataRank · unranked

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Open Access10 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (20 grants)Impact (FWCI 2.40)OA: hybridTopics (85)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (19)

Ruth B. De-Paula ORCID,Shamsideen A. Ojelade,Evelyne K. Tantry ORCID,Mikhail Y Kochukov ORCID,Suyang Bao ORCID

Live enrichment

PubMed:39146503 PMC:PMC11458016 OpenAlex:https://openalex.org/W4401604784

NIH

Grant: R01AG050631

NIH

Grant: U01AG072439

NIH

Grant: U01AG072572

NIH

Grant: U01AG061357

NIH

Grant: RF1AG057473

NIH

Grant: U01AG061356

NIH

Grant: P50HD103555

Burroughs Wellcome Fund

Grant: BWF-1017399

Alzheimer's Association fellowship

Grant: AARFD-16-442630

Wellcome Trust

Grant: 1017399

NICHD NIH HHS

Grant: P30 HD024064

National Institutes of Health

Grant: 3RF1AG057473-01S1

Deconstructing and modeling the single cell architecture of the Alzheimer brain

National Institutes of Health

Grant: 1U01AG072439-01

Functional Genomic Dissection of Alzheimer's Disease in Humans and Drosophila Models

National Institutes of Health

Grant: 3U01AG061356-02S1

Multi-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targets

National Institutes of Health

Grant: 5R01AG050631-05

Functional Validation of the CD2AP Susceptibility Network in Alzheimer's Disease

National Institutes of Health

Grant: 5U01AG061357-05

AMP-AD Brain Proteomic Network Enhancement, Validation, and Translation into CSF Biomarkers

National Institutes of Health

Grant: 1U01AG072572-01

Alzheimer variants: Propagation of shared functional changes across cellular networks

National Institutes of Health

Grant: 1P50HD103555-01

Baylor College of Medicine Intellectual and Developmental Disabilities Research Center

Eunice Kennedy Shriver National Institute of Child Health and Human Development

FWCI

2.40

Citation Percentile

0.9%

Citation Trend

2024

2025

2026

hybridLicense: cc-by-nc

journalhttps://doi.org/10.1093/hmg/ddae115

publisherhttps://doi.org/10.1093/hmg/ddae115

publisherhttps://academic.oup.com/hmg/article-pdf/33/20/1815/59622696/ddae115.pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39146503

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11458016

Fields of Study

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms0301 basic medicine03 medical and health sciences0303 health sciencesAnimalsAlzheimer DiseaseNeuronal PlasticityMiceSynapsesAdaptor Proteins, Signal TransducingCytoskeletal ProteinsMice, KnockoutHippocampusHumansNeuronsDisease Models, AnimalGenetic Predisposition to DiseaseMaleBrain

MeSH Terms

Alzheimer DiseaseAnimalsBrainCytoskeletal ProteinsDisease Models, AnimalHippocampusHumansMaleNeuronal PlasticityNeuronsSynapsesMice, KnockoutGenetic Predisposition to DiseaseAdaptor Proteins, Signal TransducingMice

Keywords

BiologyProteostasisSynaptic plasticityNeuroscienceSchaffer collateralHippocampal formationCell biologyGeneticsReceptorApolipoproteinsSynapseEndocytosisProteomicsPlasticityAlzheimer’s diseaselipid metabolismHaploinsufficiencyCd2apMale570Medical SciencesKnockout610DiseasesEndocrine System DiseasesHippocampusMiceEndocrinologyAlzheimer DiseaseMedical SpecialtiesMedicine and Health SciencesAnimalsHumansGenetic Predisposition to DiseaseAdaptor Proteins, Signal TransducingMice, KnockoutNeuronsNeuronal PlasticityAnimalDiabetesSignal TransducingAdaptor ProteinsBrainCytoskeletal ProteinsDisease Models, Animaland MetabolismDisease ModelsSynapsesOriginal Article

Sustainable Development Goals

SDG 0: Peace, Justice and strong institutionsSDG 0: Reduced inequalities