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SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy

The Journal of Immunology(2025)10.1093/jimmun/vkaf012Source: DataRank Database

SYK negatively regulates ITAM-mediated human NK cell signaling and CD19-CAR NK cell efficacy is a research paper published in The Journal of Immunology (2025). On theSindex it has a DataRank of 0. It has been cited 9 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access9 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)Impact (FWCI 3.49)OA: bronzeTopics (33)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (13)

Vincent Allain ORCID,Indrani Nayak ORCID,Jeremy B. Libang ORCID,Lilian M Quijada-Madrid,Janice Arakawa‐Hoyt ORCID

Live enrichment

PubMed:40073103 PMC:PMC11952873 OpenAlex:https://openalex.org/W4408264445

National Institutes of Health

Grant: R01AI146581

National Institutes of Health

Grant: R24 GM137787

NIAID NIH HHS

Grant: T32 AI007334

Virtual Cell

Parker Institute for Cancer Immunotherapy

National Institute for General Medical Sciences

FWCI

3.49

Citation Percentile

0.9%

Citation Trend

2025

2026

bronzeLicense: https://academic.oup.com/pages/standard-publication-reuse-rights

journalhttps://academic.oup.com/jimmunol/advance-article-pdf/doi/10.1093/jimmun/vkaf012/62351730/vkaf012.pdf

publisherhttps://academic.oup.com/jimmunol/advance-article-pdf/doi/10.1093/jimmun/vkaf012/62351730/vkaf012.pdf

publisherhttps://academic.oup.com/jimmunol/article-pdf/214/3/384/62351730/vkaf012.pdf

journalhttps://doi.org/10.1093/jimmun/vkaf012

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40073103

Fields of Study

Immune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology

MeSH Terms

Syk KinaseReceptors, Chimeric AntigenHumansKiller Cells, NaturalPhosphorylationSignal TransductionImmunotherapy, AdoptiveAntigens, CD19ZAP-70 Protein-Tyrosine KinaseImmunoreceptor Tyrosine-Based Activation Motif

Keywords

SykZAP70Jurkat cellsCell biologyTyrosine phosphorylationBiologyCytotoxic T cellSignal transductionT cellTyrosine kinaseInterleukin 21ImmunologyImmune systemBiochemistryHumanT cellsNatural killer cellsFc ReceptorsCell ActivationCell Surface Molecules

Sustainable Development Goals

SDG 0: Good health and well-being