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Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection

Nucleic Acids Research(2021)10.1093/nar/gkab152Source: DataRank Database

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection is a research paper published in Nucleic Acids Research (2021). On theSindex it has a DataRank of 0. It has been cited 45 times.

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0DataRank · unranked

Scored on demand from live citation data

Open Access45 citations

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Enrichment:Funding (9 grants)Impact (FWCI 3.05)OA: goldTopics (54)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (11)

Antonia Vitalo,Marissa A Andrew,Eduarda Mota‐Silva ORCID,Marina Kovalenko ORCID,Zoe Burch

Live enrichment

PubMed:33751106 PMC:PMC8053082 OpenAlex:https://openalex.org/W3138423661

National Institutes of Health

Grant: NS049206

NINDS NIH HHS

Grant: R01 NS049206

NIGMS NIH HHS

Grant: R01 GM097263

NICHD NIH HHS

Grant: R01 HD041012

National Institutes of Health

Grant: 5R01NS049206-08

Huntington's Disease Repeat Instability and Pathogenesis

Friedreich's Ataxia Research Alliance

Harrington Discovery Institute

Dake Family Foundation

Huntington's Disease Society of America

FWCI

3.05

Citation Percentile

0.9%

Citation Trend

2021

2022

2023

2024

2025

2026

goldLicense: CC BY NC

journalhttps://academic.oup.com/nar/article-pdf/49/7/3907/37123860/gkab152.pdf

publisherhttps://academic.oup.com/nar/article-pdf/49/7/3907/37123860/gkab152.pdf

publisherhttp://academic.oup.com/nar/article-pdf/49/7/3907/37123860/gkab152.pdf

journalhttps://doi.org/10.1093/nar/gkab152

repositoryhttps://pubmed.ncbi.nlm.nih.gov/33751106

Fields of Study

Genetic Neurodegenerative DiseasesRNA Research and SplicingDNA Repair Mechanisms0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

MutL ProteinsAnimalsCells, CulturedDNA RepairEndonucleasesFemaleFibroblastsHumansHuntington DiseaseMaleMice, Inbred C57BLOligonucleotidesProtein SplicingTrinucleotide Repeat ExpansionGenomic InstabilityMiceGene Knock-In Techniques

Keywords

EndonucleaseBiologyTrinucleotide repeat expansionRNA splicingGene isoformSomatic cellGeneticsAlternative splicingspliceMutationMolecular biologyCell biologyGeneAlleleMaleDNA RepairOligonucleotidesGenome Integrity, Repair and ReplicationFibroblastsEndonucleasesGenomic InstabilityMice, Inbred C57BLMiceHuntington DiseaseMutL ProteinsAnimalsHumansProtein SplicingFemaleGene Knock-In TechniquesCells, Cultured

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection

FAIR Checklist

Authors (11)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)