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Cooperative DNA binding mediated by KicGAS/ORF52 oligomerization allows inhibition of DNA-induced phase separation and activation of cGAS

Nucleic Acids Research(2021)10.1093/nar/gkab689Source: DataRank Database

Cooperative DNA binding mediated by KicGAS/ORF52 oligomerization allows inhibition of DNA-induced phase separation and activation of cGAS is a research paper published in Nucleic Acids Research (2021). On theSindex it has a DataRank of 0. It has been cited 51 times.

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Open Access51 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (7 grants)Impact (FWCI 2.50)OA: goldTopics (61)IDs (PubMed, PMC, OpenAlex)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Mingjian Du ORCID,Yuan Tian ORCID,Siming Ma ORCID,Jianjun Wu ORCID,Zhijian J. Chen ORCID

Live enrichment

PubMed:34387695 PMC:PMC8450086 OpenAlex:https://openalex.org/W3191584660

NIH

Grant: R01 DE026101

NIH

Grant: R00AI108793

NIH

Grant: R01AI146330

Welch Foundation

Grant: I-1389

National Institutes of Health

Grant: 5R01DE026101-02

Subversion of cGAS DNA sensing by KSHV: Roles of ORF52/KicGAS

National Institutes of Health

Grant: 5R01AI146330-04

Mechanistic Insights into Activation and Regulation of Interferon-inducible GTPase GBP2

National Institutes of Health

Grant: 5R00AI108793-03

Dissecting inflammasome anatomy: mechanistic studies and potential intervention

FWCI

2.50

Citation Percentile

0.9%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1093/nar/gkab689

publisherhttps://doi.org/10.1093/nar/gkab689

publisherhttp://academic.oup.com/nar/article-pdf/49/16/9389/40358891/gkab689.pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/34387695

repositoryhttp://europepmc.org/pmc/articles/PMC8450086

Fields of Study

interferon and immune responsesHIV Research and TreatmentImmune Cell Function and Interaction0301 basic medicine0303 health sciences03 medical and health sciencesCytosolDNA Breaks, Double-StrandedDNA DamageDNA, ViralDNA-Binding ProteinsHerpesvirus 8, HumanHost-Pathogen InteractionsHumansImmune EvasionImmunity, InnateNucleotides, CyclicNucleotidyltransferasesSarcoma, KaposiViral ProteinsCyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase

MeSH Terms

Cyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCytosolDNA DamageDNA-Binding ProteinsDNA, ViralHumansImmunity, InnateNucleotides, CyclicNucleotidyltransferasesSarcoma, KaposiViral ProteinsHerpesvirus 8, HumanDNA Breaks, Double-StrandedHost-Pathogen InteractionsImmune Evasion

Keywords

DNABiologyBiochemistryNucleic acidCell biologyDNA-binding proteinCytosolMolecular biologyEnzymeGeneTranscription factorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseNucleotidyltransferasesImmunity, InnateDNA-Binding ProteinsViral ProteinsDNA, ViralHerpesvirus 8, HumanHost-Pathogen InteractionsHumansDNA Breaks, Double-StrandedNucleotides, CyclicSarcoma, KaposiDNA DamageImmune Evasion

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being