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The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulatesKRASexpression in pancreatic ductal adenocarcinoma cells

Nucleic Acids Research(2022)10.1093/nar/gkac172Source: DataRank Database

The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulatesKRASexpression in pancreatic ductal adenocarcinoma cells is a research paper published in Nucleic Acids Research (2022). On theSindex it has a DataRank of 1.6. It has been cited 62 times, with 56 citing works in its 1-hop citation network.

N/A

1.6DataRank · unranked

Scored on demand from live citation data

Open Access62 citations · 56 citing works in its network

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Linked data & code

doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (15 grants)Impact (FWCI 4.39)OA: goldTopics (32)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 38%Citation Network 62%

Base Score Contribution

0.621

From this paper's citation signal

Citation Network Contribution

1.0

From 45 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 56 citers.

Protein-Scaffolded DNA Nanostructures for Imaging of Apurinic/Apyrimidinic Endonuclease 1 Activity in Live Cells
Analytical Chemistry202323 citations26 referencesContributes 0.122
Enzyme-Activated Biosensor Assisted by Enzymatic Rolling Circle Amplification for Sensitive Detection of APE1 and Imaging in Vivo
Analytical Chemistry202510 citations31 referencesContributes 0.077
One-Pot Rlock-Mediated CRISPR/Cas12a-Driven RCA Cycle for Rapid and High-Sensitive APE1 Detection
Analytical Chemistry202510 citations37 referencesContributes 0.065
PAMAM-Based DNA Fluorescence Nanoprobe for Rapid Whole Cellular APE1 Detection and Imaging
Analytical Chemistry20256 citations41 referencesContributes 0.047
In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer
Redox Biology202317 citations62 referencesContributes 0.047

Authors (9)

Yingling Chen,Heyu Song,Irine Khutsishvili ORCID,Luis A. Marky ORCID,Sutapa Ray ORCID

Live enrichment

PubMed:35286386 PMC:PMC8990529 OpenAlex:https://openalex.org/W4220940756

National Institutes of Health

Grant: R03CA235214

National Institutes of Health

Grant: R01CA163649

National Institutes of Health

Grant: R01CA216853

Nebraska Department of Health and Human Services

Grant: LB506

National Science Foundation

Grant: MCB- 1912587

NIGMS NIH HHS

Grant: P20 GM103427

NCI NIH HHS

Grant: P30 CA036727

NIGMS NIH HHS

Grant: P30 GM106397

National Institutes of Health

Grant: 3P20GM103427-23S2

Nebraska Research Network in Functional Genomics

National Institutes of Health

Grant: 3R01CA216853-03S1

Metabolic Regulation of Tumor Progression, Metastasis and Chemoresistance by SIRT5/ELK3 signaling in Pancreatic Cancer

National Institutes of Health

Grant: 1R03CA235214-01A1

Elucidating the role of acetylation of APE1 in tumor growth and chemoresistance

National Institutes of Health

Grant: 5P30CA036727-23

CORE--Confocal Microscopy

National Science Foundation

Grant: 1912587

Sequence Specific Targeting of RNA Using Complementary Strands: Energetics, Kinetics and Hydration

National Institutes of Health

Grant: 2R01CA163649-06A1

Targeting MUC1-Mediated Tumor-Stromal Metabolic Cross-Talk in Pancreatic Cancer

National Institutes of Health

Grant: 5P30GM106397-03

Research Pilot Project Program

FWCI

4.39

Citation Percentile

1.0%

Citation Trend

2022

2023

2024

2025

2026

goldLicense: cc-by

journalhttps://academic.oup.com/nar/article-pdf/50/6/3394/43246359/gkac172.pdf

publisherhttps://academic.oup.com/nar/article-pdf/50/6/3394/43246359/gkac172.pdf

journalhttps://doi.org/10.1093/nar/gkac172

repositoryhttps://pubmed.ncbi.nlm.nih.gov/35286386

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/8990529

Fields of Study

DNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery0301 basic medicine03 medical and health sciences

MeSH Terms

DNAEndonucleasesHumansPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Carcinoma, Pancreatic DuctalDNA-(Apurinic or Apyrimidinic Site) LyaseG-Quadruplexes

Keywords

BiologyKRASCancer researchMolecular biologyCarcinogenesisGene knockdownDNA damageDNAGeneMutationGeneticsG-QuadruplexesPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Gene regulation, Chromatin and EpigeneticsDNA-(Apurinic or Apyrimidinic Site) LyaseHumansEndonucleasesCarcinoma, Pancreatic Ductal

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

Related Papers (2)

Obesity increases genomic instability at DNA repeat-mediated endogenous mutation hotspots

N/A

0.595DataRank · unranked

Nature Communications(2024)

co-cited

10.1038/s41467-024-50006-8

Formation and processing of DNA damage substrates for the hNEIL enzymes

N/A

2.9DataRank · unranked

Free Radical Biology and Medicine(2017)

co-cited

10.1016/j.freeradbiomed.2016.11.030

The human AP-endonuclease 1 (APE1) is a DNA G-quadruplex structure binding protein and regulatesKRASexpression in pancreatic ductal adenocarcinoma cells

FAIR Checklist

DataRank Breakdown

Top 5 citers driving the network score

Authors (9)

Funding (15 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)

Related Papers (2)