FAVOR: functional annotation of variants online resource and annotator for variation across the human genome is a dataset published in Nucleic Acids Research (2022). On theSindex it has a DataRank of 2.7, placing it in the top 8.1% of the data-sharing corpus. It has been cited 143 times, with 100 citing works in its 1-hop citation network. Its calibrated FAIR score is 33/100.
Ranks in the top 8% for downstream scientific impact
Linked data & code
DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Full FAIR picture · advisory
The headline score is computed from the scored criteria — the fact-shaped checks (a repository, an accession, a licence) that two independent models agree on. The advisory criteria below are real FAIR guidance but rest on judgment calls that models read differently, so they inform without moving the number.
“The FAVOR essential database (containing 20 essential functional annotation scores) for all possible SNVs (8 812 917 339) and observed Indels (79 997 898) in Build GRCh38/hg38 is hosted on Harvard Dataverse ( https://doi.org/10.7910/DVN/1VGTJI).”— not found in the paper; verdict downgraded
The paper provides DOIs from Harvard Dataverse, which are persistent identifiers in the DOI scheme. [downgraded to 'partial' — no verifiable quote from the paper]
RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit · RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier' · FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'
“The FAVOR essential database (containing 20 essential functional annotation scores) for all possible SNVs (8 812 917 339) and observed Indels (79 997 898) in Build GRCh38/hg38 is hosted on Harvard Dataverse ( https://doi.org/10.7910/DVN/1VGTJI).”— not found in the paper; verdict downgraded
Harvard Dataverse is a named repository listed in re3data and FAIRsharing. [downgraded to 'partial' — no verifiable quote from the paper]
RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed ( · NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived · NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten
“The FAVOR essential database (containing 20 essential functional annotation scores) for all possible SNVs (8 812 917 339) and observed Indels (79 997 898) in Build GRCh38/hg38 is hosted on Harvard Dataverse ( https://doi.org/10.7910/DVN/1VGTJI).”— not found in the paper; verdict downgraded
The dataset identifiers (DOIs) appear only in the body text (Data Availability section), not in the reference list. [downgraded to 'no' — no verifiable quote from the paper]
FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first- · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes · FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'
Advisory · not in the published score
“The FAVOR essential database (containing 20 essential functional annotation scores) for all possible SNVs (8 812 917 339) and observed Indels (79 997 898) in Build GRCh38/hg38 is hosted on Harvard Dataverse ( https://doi.org/10.7910/DVN/1VGTJI). The FAVOR full database (containing 160 essential functional annotation scores) for all possible SNVs (8 812 917 339) and observed Indels (79 997 898) in Build GRCh38/hg38 is hosted on Harvard Dataverse ( https://doi.org/10.7910/DVN/KFUBKG).”— not found in the paper; verdict downgraded
The Data Availability section points to repository records (Harvard Dataverse with DOIs), which is Colavizza category 3. [downgraded to 'partial' — no verifiable quote from the paper]
Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li · Springer Nature research data policy — Data Availability Statements: standard statement templat · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes
“Specifically, it stores 160 functional annotation values for all possible 8,892,915,237 SNVs, and 79,997,898 observed indels in 20 TB of space.”
The dataset's content is described in running prose, but there is no itemised inventory (section, table, or list) of files or variables. [majority verdict 'partial' (4/5 passes agreed)]
RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential) · FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability' · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'
“The FAVOR essential database (containing 20 essential functional annotation scores) for all possible SNVs (8 812 917 339) and observed Indels (79 997 898) in Build GRCh38/hg38 is hosted on Harvard Dataverse ( https://doi.org/10.7910/DVN/1VGTJI).”— not found in the paper; verdict downgraded
The paper gives a repository link with no stated precondition (embargo, registration, or application), implying immediate open access. [downgraded to 'partial' — no verifiable quote from the paper] [majority verdict 'partial' (3/5 passes agreed)]
RDA-A1.1-01D — 'Data is accessible through a free access protocol' · FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'
Advisory · not in the published score
“FAVOR offers a comprehensive solution for the application of whole genome variant functional annotations, including open access and downloadable database”
The paper explicitly labels the data as 'open access' in the discussion section. [majority verdict 'yes' (3/5 passes agreed)]
FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · RDA-A1-01M — metadata contains information to enable the user to get access to the data · COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl
“FAVOR offers a comprehensive solution for the application of whole genome variant functional annotations, including open access and downloadable database”
The data are not sensitive or human-subject data; they are a public variant annotation database. No gatekeeper is named.
NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee · RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and · NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse
“FAVOR offers a comprehensive solution for the application of whole genome variant functional annotations, including open access and downloadable database”
The paper does not mention any retention period, preservation commitment, or availability timing beyond the statement that the data are accessible now.
NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines · NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy' · RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'
The paper does not specify the file format of the released data. [majority verdict 'no' (2/5 passes agreed)]
FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co · RDA-R1.3-02D — data is expressed in a machine-understandable community standard · RDA-I1-01D — data uses a knowledge representation expressed in a standardised format
Advisory · not in the published score
“The FAVOR database is built using the PostgreSQL relational DBMS (Database Management System) for storing and retrieving variant annotation data and using a multi-table design that supports efficient integration of different types of scores. Specifically, it stores 160 functional annotation values for all possible 8,892,915,237 SNVs, and 79,997,898 observed indels in 20 TB of space.”— not found in the paper; verdict downgraded
The paper does not name a community-standard data or metadata checklist, ontology, or schema applied to the released dataset. Reference genome build GRCh38 is mentioned but not as a standard for the data itself. [majority verdict 'no' (4/5 passes agreed)]
RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential) · RDA-R1.3-01D — 'Data complies with a community standard' · RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'
The paper cites external resources (e.g., gnomAD, TOPMed) with reference numbers but does not provide identifiers (DOIs, accessions) for those resources in the text. [majority verdict 'no' (4/5 passes agreed)]
RDA-I3-01M — '(meta)data include references to other (meta)data' · RDA-I3-03M — 'metadata includes qualified references to other metadata' · FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'
The paper does not state any license for the data. The CC-BY license applies only to the article.
RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu · RDA-R1.1-02M — 'Metadata refers to a standard reuse licence' · RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'
No version token or date is given for the dataset snapshot. The DOIs may resolve to versioned records, but the paper does not state a version. [majority verdict 'no' (4/5 passes agreed)]
DataCite Metadata Schema 4.6 — the 'Version' property · RDA-R1.2-01M — provenance information (which version was used is provenance) · NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'
“FAVORannotator is an open-source annotation tool available in the GitHub repository ( https://github.com/zhouhufeng/FAVORannotator).”— not found in the paper; verdict downgraded
The paper provides a machine-resolvable URL to the code repository (GitHub), which is a class 1 locator. [downgraded to 'partial' — no verifiable quote from the paper] [majority verdict 'partial' (4/5 passes agreed)]
NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code' · FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear · FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)
“National Human Genome Research Institute [U01-HG009088, U01-HG012064]; National Cancer Institute [R35-CA197449, U19-CA203654]; National Heart, Lung, and Blood Institute [R01-HL163560].”
The paper lists specific award/grant numbers for each funder. [majority verdict 'yes' (3/5 passes agreed)]
DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award · Crossref Funder Registry — canonical funder identifiers for funding metadata · RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco
Advisory · not in the published score
“The FAVOR database is built using the PostgreSQL relational DBMS (Database Management System) for storing and retrieving variant annotation data”— not found in the paper; verdict downgraded
The paper names a specific tool (PostgreSQL) used to build the database, providing a named instrument/software for data production. [downgraded to 'partial' — no verifiable quote from the paper]
RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa · FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati · W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance
“These functional annotations are organized into 12 major types, including Variant Category, Allele Frequencies (AFs), ClinVar, Integrative Scores, Protein Functions, Conservation, Epigenetics, Chromatin States, Local Nucleotide Diversity, Mutation Density, Mappability and Proximity (Supplementary Table S3).”— not found in the paper; verdict downgraded
Variable definitions are provided in Supplementary Table S3 inside the article, not as a separate documentation object shipped with the data. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (3/5 passes agreed)]
RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data' · NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t
Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.745
From this paper's citation signal
Citation Network Contribution
2.0
From 84 citing papers with measurable signal
Ranked by each citer's contribution to N(p) — log1p(Cq) divided by its reference count — out of 100 citers.
National Human Genome Research Institute
Grant: U01-HG009088
National Human Genome Research Institute
Grant: U01-HG012064
National Cancer Institute
Grant: R35-CA197449
National Cancer Institute
Grant: U19-CA203654
National Heart, Lung, and Blood Institute
Grant: R01-HL163560
NHLBI NIH HHS
Grant: R01 HL163560
NHGRI NIH HHS
Grant: U01 HG009088
NCI NIH HHS
Grant: U19 CA203654
NHGRI NIH HHS
Grant: U01 HG012064
NIH HHS
Grant: R03 OD030608
NCI NIH HHS
Grant: R35 CA197449
NIEHS NIH HHS
Grant: P42 ES030990
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Grant: 5U01HL054464-07
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Grant: 5R01HL092577-02
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Grant: 5R01HL133040-02
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Swedish Research Council
Grant: unidentified
unidentified
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Grant: 3UL1TR001079-02S1
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Grant: 2R01MH101244-11
Functional and population genetic architectures of complex disease
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Grant: N01HC095169-004
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Grant: N01HC095165-001
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Grant: N01HC085081-016
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Grant: N01HC095159-011
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Grant: 5R01HL071258-04
MESA Family Study
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Grant: 5U01HL054509-09
HYPERGEN-NC
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Grant: 3R01HL098433-05S1
ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPS
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Large Scale Sequencing and Analysis of Genomes
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MESA Family Study
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Whole Genome Sequencing to Identify Causal Genetic Variants Influencing CVD Risk
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CORE--BIOSTATISTICS
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GCRC-RENOVATION
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FWCI
20.18
Citation Percentile
1.0%
Influential Citations
9
Citation Trend
Fields of Study
MeSH Terms
Keywords
Sustainable Development Goals