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Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization

Nucleic Acids Research(2022)10.1093/nar/gkac995Source: DataRank Database

Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization is a research paper published in Nucleic Acids Research (2022). On theSindex it has a DataRank of 0. It has been cited 6 times.

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Open Access6 citations

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Enrichment:Funding (9 grants)OA: goldTopics (30)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Hongyu Zhang ORCID,Shanni Yamaki,Chenyu Yang ORCID,David D. McKemy ORCID,Michael R. Lieber ORCID

Live enrichment

PubMed:36321646 PMC:PMC9723645

National Institutes of Health

Grant: R35ES028343

National Institutes of Health

Grant: 1RM1GM130450

National Institutes of Health

Grant: R35 GM118009

National Institutes of Health

Grant: R01 NS106888

NIGMS NIH HHS

Grant: RM1 GM130450

National Institutes of Health

Grant: 5R35ES028343-04

Hypermutation in Bacteria and Humans

National Institutes of Health

Grant: 5R35GM118009-10

Site-Specific Recombination in Human Health & Disease

National Institutes of Health

Grant: 5R01NS106888-02

Molecular and cellular mechanisms of cold allodynia

National Institutes of Health

Grant: 1RM1GM130450-01

Creation and Repair of Postreplicative DNA Gaps

goldLicense: CC BY NC

GOLDhttps://academic.oup.com/nar/article-pdf/50/20/11738/47609129/gkac995.pdf

publisherhttps://academic.oup.com/nar/article-pdf/50/20/11738/47609129/gkac995.pdf

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/9723645

Europe_PMChttps://europepmc.org/articles/PMC9723645

Europe_PMChttps://europepmc.org/articles/PMC9723645?pdf=render

Fields of Study

MedicineBiology0301 basic medicine0303 health sciences03 medical and health sciences

MeSH Terms

AnimalsHumansMicePainDiabetes Mellitus, Type 2Cytidine DeaminaseImmunoglobulin Variable RegionAntibody AffinitySomatic Hypermutation, ImmunoglobulinSingle-Chain AntibodiesSingle-Domain AntibodiesY-Family DNA Polymerases

Keywords

Nucleic Acid EnzymesAntibody AffinityImmunoglobulin Variable RegionPainY-Family DNA PolymerasesSingle-Domain AntibodiesMiceDiabetes Mellitus, Type 2Cytidine DeaminaseAnimalsHumansSomatic Hypermutation, ImmunoglobulinSingle-Chain Antibodies

Sustainable Development Goals

SDG 3: 3. Good health

Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization

FAIR Checklist

Authors (8)

Funding (9 grants)

Open Access

Topics

Annotations (Europe PMC)