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The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma

Nucleic Acids Research(2024)10.1093/nar/gkae1121Source: DataRank Database

The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma is a research paper published in Nucleic Acids Research (2024). On theSindex it has a DataRank of 0.324. It has been cited 6 times, with 6 citing works in its 1-hop citation network.

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0.324DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access6 citations · 6 citing works in its network

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Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE274233 GSE274234 GSE274250

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (14 grants)OA: goldTopics (57)IDs (PubMed)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 90%Citation Network 10%

Base Score Contribution

0.292

From this paper's citation signal

Citation Network Contribution

0.0321

From 4 citing papers with measurable signal

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Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 6 citers.

The Genetic and Epigenetic Alterations of Plasmablastic Lymphoma: A Narrative Review
Cancers20252 citations87 referencesContributes 0.013
NSD2 exacerbates metabolic dysfunction-associated steatotic liver disease progression by suppressing TFEB-mediated autophagy-lysosomal pathway
Metabolism20251 citations55 referencesContributes 0.013
Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities
Biomolecules20257 citations208 referencesContributes 0.010
Structural landscape of H3K27me3 recognition by protein domains and their potential for inhibition
Journal of Biological Chemistry20261 citations278 referencesContributes 0.002
Many faces of mammalian NSD methyltransferases
Cellular & Molecular Biology Letters20260 citations126 referencesContributes 0.000

Authors (11)

Charlotte L Kaestner,Michela Ghitti ORCID,Giacomo Quilici ORCID,Paolo Cocomazzi ORCID,Jianping Li ORCID

Live enrichment

PubMed:39656918

PRACE

Grant: 2020225324

Associazione Italiana Ricerca sul Cancro

Grant: IG-21440

Florida Department of Health

Grant: 21L05

Florida Department of Health

Grant: NCI R01 CA195732

Leukemia and Lymphoma society

Grant: 7021-20

NIH

Grant: P30CA247796

National Institutes of Health

Grant: 3P30CA247796-01A1S1

UF Health Cancer Center Support Grant - Training Navigator Supplement

National Institutes of Health

Grant: 5R01CA195732-04

The Role of MMSET in the Pathogenesis and Progression of Lymphoid Malignancy

NCI NIH HHS

Grant: R01 CA195732

Myeloma Solution Fund

University of Florida Health Cancer Center

FEBS

CINECA

EMBO

goldLicense: cc-by-nc

publisherhttps://doi.org/10.1093/nar/gkae1121

publisherhttps://academic.oup.com/nar/article-pdf/53/1/gkae1121/60958098/gkae1121.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC11724302/pdf/gkae1121.pdf

https://pubmed.ncbi.nlm.nih.gov/39656918

http://dx.doi.org/10.1093/nar/gkae1121

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciencesMultiple MyelomaHumansHistone-Lysine N-MethyltransferaseHistonesCell AdhesionMethylationRepressor ProteinsGene Expression Regulation, NeoplasticCell Line, TumorTranscription, GeneticProtein DomainsMolecular Dynamics Simulation

MeSH Terms

Multiple MyelomaHumansHistone-Lysine N-MethyltransferaseHistonesCell AdhesionMethylationRepressor ProteinsGene Expression Regulation, NeoplasticCell Line, TumorTranscription, GeneticProtein DomainsMolecular Dynamics Simulation

Keywords

Investigative Techniquestumor570Transcription, Geneticprotein domainsMolecular Dynamics SimulationMethylationHistonesNeoplasmsCell Line, TumorEnzymes and CoenzymesCell AdhesionHumansAmino Acidsrepressor proteinsand Proteins500Molecular and Structural Biologycell linegene expression regulationCell BiologyHistone-Lysine N-Methyltransferaseneoplasticmultiple myelomaGene Expression Regulation, NeoplasticchromatingeneticGenetic PhenomenatranscriptionPeptides