Pilot corpus: NIH-funded biomedical datasets. Any DOI can be scored on demand — network effects sharpen as coverage grows.

PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells

Nucleic Acids Research(2024)10.1093/nar/gkae319Source: DataRank Database

PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells is a research paper published in Nucleic Acids Research (2024). On theSindex it has a DataRank of 0.442. It has been cited 9 times, with 8 citing works in its 1-hop citation network.

N/A

0.442DataRank · unranked

Scored on demand from live citation data

Deposits data Open Access9 citations · 8 citing works in its network

Download PDF

Cite:

Linked data & code

geo pdb

Data availability

Repositories this paper deposited data in (declared in PubMed).

GEOGSE252916 GSE212760 GSE256352

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (10 grants)Impact (FWCI 1.68)OA: goldTopics (72)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

FAIR checklist signals are shown for context only and do not affect DataRank scoring.

Run a calibrated FAIR evaluation for this paper →

We only score data papers we can read in full — never from an abstract alone.

DataRank Breakdown

Base Score 78%Citation Network 22%

Base Score Contribution

0.345

From this paper's citation signal

Citation Network Contribution

0.0971

From 6 citing papers with measurable signal

Learn more about DataRank methodology →

Top 5 citers driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 8 citers.

Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4
Frontiers in Cell and Developmental Biology20254 citations51 referencesContributes 0.032
Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB
bioRxiv (Cold Spring Harbor Laboratory)20245 citations74 referencesContributes 0.024
An in-depth review of the function of RNA-binding protein FXR1 in neurodevelopment
Cell and Tissue Research20246 citations93 referencesContributes 0.021
Infection with Mycobacterium tuberculosis orchestrates the PRMT5-dependent methylation of NCOA4 to govern host ferroptosis
bioRxiv (Cold Spring Harbor Laboratory)20251 citations48 referencesContributes 0.014
circPLEKHM1 promotes tumor growth and metastasis through enhancing FXR1-mediated protein translation in PDAC
Cancer Letters20261 citations50 referencesContributes 0.014

Authors (11)

Mrinmoyee Majumder ORCID,Shasha Yin ORCID,Charles Brobbey,Joseph A. Karam ORCID,Breege V. Howley ORCID

Live enrichment

PubMed:38709899 PMC:PMC11229354 OpenAlex:https://openalex.org/W4396659124

National Institutes of Health

Grant: R01DE030013

National Institutes of Health

Grant: R21DE032461

NCI NIH HHS

Grant: P30 CA138313

NCI NIH HHS

Grant: R01 CA266522

NIGMS NIH HHS

Grant: P20 GM148302

NCI NIH HHS

Grant: P30 CA118100

National Institutes of Health

Grant: 5P30CA138313-09

Medical University of South Carolina - Cancer Center Support Grant

National Institutes of Health

Grant: 3P30CA118100-18S1

University of New Mexico Cancer Center Support Grant

National Institutes of Health

Grant: 1R01DE030013-01

Intersections of RNA-binding proteins and T-cells in oral epithelial plasticity

National Institutes of Health

Grant: 1R21DE032461-01

Targeting of RNA-binding protein FXR1 in HNSCC

FWCI

1.68

Citation Percentile

0.8%

Citation Trend

2024

2025

2026

goldLicense: cc-by

journalhttps://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae319/57420568/gkae319.pdf

publisherhttps://academic.oup.com/nar/advance-article-pdf/doi/10.1093/nar/gkae319/57420568/gkae319.pdf

publisherhttps://academic.oup.com/nar/article-pdf/52/12/7225/58470188/gkae319.pdf

journalhttps://doi.org/10.1093/nar/gkae319

repositoryhttps://pubmed.ncbi.nlm.nih.gov/38709899

Fields of Study

Cancer-related gene regulationRNA modifications and cancerEpigenetics and DNA Methylation0301 basic medicine0303 health sciences03 medical and health sciencesHumansProtein-Arginine N-MethyltransferasesRNA-Binding ProteinsArginineMethylationCell ProliferationRNA, MessengerCell Line, TumorProtein BindingG-QuadruplexesGene Expression Regulation, NeoplasticRepressor ProteinsProtein Processing, Post-TranslationalNeoplasmsHEK293 CellsProtein Stability

MeSH Terms

ArginineHumansMethylationNeoplasmsProtein-Arginine N-MethyltransferasesProtein BindingProtein Processing, Post-TranslationalRepressor ProteinsRNA, MessengerGene Expression Regulation, NeoplasticRNA-Binding ProteinsCell Line, TumorCell ProliferationG-QuadruplexesProtein StabilityHEK293 Cells

Keywords

Protein arginine methyltransferase 5BiologyRNA-binding proteinMethylationRNAGene expressionMolecular biologyArginineRNA methylationCancer cellRNA recognition motifMessenger RNABiochemistryCell biologyMethyltransferaseGeneCancerAmino acidGeneticsProtein-Arginine N-MethyltransferasesProtein StabilityRNA-Binding ProteinsG-QuadruplexesGene Expression Regulation, NeoplasticRepressor ProteinsHEK293 CellsCell Line, TumorNeoplasmsRNA and RNA-protein complexesHumansRNA, MessengerProtein Processing, Post-TranslationalCell ProliferationProtein Binding

Sustainable Development Goals

SDG 0: Good health and well-being