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Cryo-EM structure of AAV2 Rep68 bound to integration site AAVS1: insights into the mechanism of DNA melting

Nucleic Acids Research(2025)10.1093/nar/gkaf033Source: DataRank Database

Cryo-EM structure of AAV2 Rep68 bound to integration site AAVS1: insights into the mechanism of DNA melting is a research paper published in Nucleic Acids Research (2025). On theSindex it has a DataRank of 0. It has been cited 8 times.

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Open Access8 citations

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Enrichment:Funding (16 grants)Impact (FWCI 8.78)OA: goldTopics (47)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Brandon Braud,Karen C. Hernández-Ramírez,Vishaka Santosh,Alexander Washington,Carlos Escalante ORCID

Live enrichment

PubMed:39883011 PMC:PMC11780844 OpenAlex:https://openalex.org/W4406973405

National Institute of General Medical Sciences

Grant: 2R01GM124204

NIH Common Fund Transformative High-Resolution Cryo-Electron Microscopy Program

Grant: U24GM1129539

NIGMS

Grant: R24GM154192

Simons Foundation

Grant: SF349247

NIH

Grant: U24GM129547

NIGMS NIH HHS

Grant: R25 GM089614

NIGMS NIH HHS

Grant: R01 GM124204

Office of Biological and Environmental Research

NY State Assembly

NIH Postbaccalaureate Research Program

NIH HHS

National Institutes of Health

Office of Biological and Environmental Research

NIH Postbaccalaureate Research Program

NIH HHS

NY State Assembly

FWCI

8.78

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by-nc

journalhttps://doi.org/10.1093/nar/gkaf033

publisherhttps://doi.org/10.1093/nar/gkaf033

publisherhttps://academic.oup.com/nar/article-pdf/53/3/gkaf033/61698369/gkaf033.pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/39883011

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/11780844

Fields of Study

Virus-based gene therapy researchRNA Research and SplicingCRISPR and Genetic EngineeringCryoelectron MicroscopyDependovirusDNA-Binding ProteinsDNA, ViralModels, MolecularNucleic Acid DenaturationProtein BindingViral ProteinsDNAProtein DomainsBinding SitesDNA ReplicationAdenosine Triphosphate

MeSH Terms

Protein DomainsDependovirusAdenosine TriphosphateBinding SitesDNADNA ReplicationDNA HelicasesDNA-Binding ProteinsDNA, ViralHumansModels, MolecularNucleic Acid DenaturationProtein BindingViral ProteinsVirus IntegrationCryoelectron Microscopy

Keywords

DNABiologyDNA replicationDNA clampHelicaseReplication protein ANucleotideDNA-binding proteinBiophysicsBiochemistryPolymerase chain reactionReverse transcriptaseGeneRNATranscription factor

Sustainable Development Goals

SDG 0: Responsible consumption and production