The Reactome Knowledgebase 2026 is a dataset published in Nucleic Acids Research (2025). On theSindex it has a DataRank of 0.590, placing it in the top 33.3% of the data-sharing corpus. It has been cited 32 times, with 29 citing works in its 1-hop citation network. Its calibrated FAIR score is 42/100.
Ranks in the top 33% for downstream scientific impact
Linked data & code
DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Full FAIR picture · advisory
The headline score is computed from the scored criteria — the fact-shaped checks (a repository, an accession, a licence) that two independent models agree on. The advisory criteria below are real FAIR guidance but rest on judgment calls that models read differently, so they inform without moving the number.
“All Reactome data are available in various formats from our downloads page ( https://reactome.org/download-data ) and from Zenodo ( https://zenodo.org/records/15731221 )”
The paper gives a web URL (zenodo.org/records/15731221) rather than a persistent identifier string such as a DOI or Handle. [majority verdict 'partial' (3/5 passes agreed)]
RDA-F1-01D — FAIR Data Maturity Model: 'Data is identified by a persistent identifier' (priorit · RDA-F1-02D — FAIR Data Maturity Model: 'Data is identified by a globally unique identifier' · FsF-F1-02D — F-UJI/FAIRsFAIR: 'Data is assigned a persistent identifier'
“All Reactome data are available in various formats from our downloads page (https://reactome.org/download-data) and from Zenodo (https://zenodo.org/records/15731221)”— not found in the paper; verdict downgraded
Zenodo is named as a repository; it is a curated archive listed in re3data. [downgraded to 'partial' — no verifiable quote from the paper] [majority verdict 'partial' (3/5 passes agreed)]
RDA-F4-01M — FAIR Data Maturity Model: metadata is offered so it can be harvested and indexed ( · NIH DMS Policy Element 4 (NOT-OD-21-014) — name the repository where data will be archived · NSTC Desirable Characteristics of Data Repositories (2022) — 'Long-Term Sustainability', 'Reten
“from Zenodo (https://zenodo.org/records/15731221)”— not found in the paper; verdict downgraded
The dataset identifier (Zenodo URL) appears only in the body text of the Data availability section, not as a reference-list entry. [downgraded to 'no' — no verifiable quote from the paper] [majority verdict 'no' (3/5 passes agreed)]
FORCE11 Joint Declaration of Data Citation Principles (2014) — data should be cited as a first- · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes · FsF-F3-01M — F-UJI: 'Metadata includes the identifier of the data it describes'
Advisory · not in the published score
“All Reactome data are available in various formats from our downloads page ( https://reactome.org/download-data ) and from Zenodo ( https://zenodo.org/records/15731221 ), as is our users’ guide and related documentation ( https://zenodo.org/records/15808136 ), and software for our pathway browser ( https://doi.org/10.5281/zenodo.17379609 ) and React-to-me chatbot ( https://doi.org/10.5281/zenodo.17379758 ), under terms that allow free reuse and redistribution.”
The statement points to a repository record (Zenodo) with a persistent link, which is Colavizza category 3. [majority verdict 'yes' (3/5 passes agreed)]
Colavizza, Hrynaszkiewicz, Staden, Whitaker & McGillivray (2020), 'The citation advantage of li · Springer Nature research data policy — Data Availability Statements: standard statement templat · RDA-F3-01M — metadata clearly and explicitly includes the identifier of the data it describes
“Table 1. Reactome content; version 86 (September 2023) versus 94 (September 2025)”
The paper provides an itemised inventory of the dataset's content in Table 1, which is a structured data description.
RDA-F2-01M — 'Rich metadata is provided to allow discovery' (priority Essential) · FsF-F2-01M — F-UJI: 'Metadata includes descriptive core elements to support data findability' · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data'
“All Reactome data are available in various formats from our downloads page ( https://reactome.org/download-data ) and from Zenodo ( https://zenodo.org/records/15731221 ), under terms that allow free reuse and redistribution.”— not found in the paper; verdict downgraded
The route to the data is given with no precondition; the data are freely available now. [downgraded to 'partial' — no verifiable quote from the paper] [majority verdict 'partial' (4/5 passes agreed)]
RDA-A1.1-01D — 'Data is accessible through a free access protocol' · FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · NSTC Desirable Characteristics of Data Repositories (2022) — 'Free and Easy Access'
Advisory · not in the published score
“The Reactome Knowledgebase ( https://reactome.org ) is a freely accessible, expert-curated, open-source, and open-data resource”
The abstract explicitly labels the data as 'freely accessible' and 'open-data', which is a natural-language equivalent of the open-access level. [majority verdict 'yes' (3/5 passes agreed)]
FsF-A1-01M — F-UJI: 'Metadata contains access level and access conditions of the data' · RDA-A1-01M — metadata contains information to enable the user to get access to the data · COAR Controlled Vocabularies — Access Rights v1.0 (open / embargoed / restricted / metadata-onl
The data are not sensitive human-subject data; no gatekeeper is named because none is needed.
NIH Genomic Data Sharing Policy (NOT-OD-14-124) — controlled-access via a Data Access Committee · RDA-A1.2-01D — 'Data is accessible through an access protocol that supports authentication and · NIH DMS Policy Element 5 (NOT-OD-21-014) — Access, Distribution, or Reuse Considerations (conse
“Reactome was awarded CoreTrustSeal certification, independently validating our sustainability, transparency, governance, and commitment to longterm preservation.”
The paper asserts a commitment to long-term preservation through CoreTrustSeal certification, which is a persistence commitment.
NIH DMS Plan Element 4 (NOT-OD-21-014) — Data Preservation, Access, and Associated Timelines · NSTC Desirable Characteristics (2022), Organizational Infrastructure: 'Retention Policy' · RDA-A2-01M — 'Metadata is guaranteed to remain available after data is no longer available'
The paper states 'various formats' but does not name any specific file format token for the data.
FsF-R1.3-02D — F-UJI: 'Data is available in a file format recommended by the target research co · RDA-R1.3-02D — data is expressed in a machine-understandable community standard · RDA-I1-01D — data uses a knowledge representation expressed in a standardised format
Advisory · not in the published score
“resulting in an extended version of a classic metabolic map generally compliant with the SBGN process description standard”
SBGN is a community standard for biological pathway diagrams, registered in FAIRsharing. [majority verdict 'yes' (4/5 passes agreed)]
RDA-R1.3-01M — 'Metadata complies with a community standard' (priority Essential) · RDA-R1.3-01D — 'Data complies with a community standard' · RDA-I2-01M — '(Meta)data use vocabularies that follow FAIR principles'
No identifiers for external resources (e.g., UniProt accession, database build ID) are provided in the text. [majority verdict 'no' (3/5 passes agreed)]
RDA-I3-01M — '(meta)data include references to other (meta)data' · RDA-I3-03M — 'metadata includes qualified references to other metadata' · FsF-I3-01M — F-UJI: 'Metadata includes links between the data and its related entities'
The data availability statement mentions 'free reuse and redistribution' but does not name a standard open license (e.g., CC0, CC BY). The CC BY 4.0 license mentioned applies only to the article and the icon library, not to the entire dataset.
RDA-R1.1-01M — 'Metadata includes information about the licence under which the data can be reu · RDA-R1.1-02M — 'Metadata refers to a standard reuse licence' · RDA-R1.1-03M — 'Metadata refers to a machine-understandable reuse licence'
“Reactome (version 94; September 2025)”
A version token (version 94) is stated for the data.
DataCite Metadata Schema 4.6 — the 'Version' property · RDA-R1.2-01M — provenance information (which version was used is provenance) · NSTC Desirable Characteristics of Data Repositories (2022) — 'Provenance', 'Retention Policy'
“software for our pathway browser ( https://doi.org/10.5281/zenodo.17379609 ) and React-to-me chatbot ( https://doi.org/10.5281/zenodo.17379758 )”
Machine-resolvable DOIs are given for the study's own code. [majority verdict 'yes' (3/5 passes agreed)]
NIH DMS Policy Element 2 (NOT-OD-21-014) — 'Related Tools, Software and/or Code' · FAIR4RS Principles v1.0 (Chue Hong et al., 2022; RDA/FORCE11/ReSA) — FAIR Principles for Resear · FORCE11 Software Citation Principles (Smith, Katz & Niemeyer, 2016, PeerJ CS 2:e86)
“The development of Reactome is supported by grants from the National Institutes of Health (U24HG012198 and U24HG012198-02S1 for Core Trust Seal development; U24HG011851)”
Specific award/grant numbers are provided for the funding.
DataCite Metadata Schema 4.6 — 'FundingReference' property (funderName, funderIdentifier, award · Crossref Funder Registry — canonical funder identifiers for funding metadata · RDA-F2-01M — rich metadata provided to allow discovery (funding is part of the descriptive reco
Advisory · not in the published score
No specific instruments, assays, kits, or software versions used to produce the data are named; the process is described generically as expert curation.
RDA-R1.2-01M — 'Metadata includes provenance information according to community- specific standa · FsF-R1.2-01M — F-UJI: 'Metadata includes provenance information about data creation or generati · W3C PROV-O (W3C Recommendation, 2013) — the entity/activity/agent model of provenance
“as is our users’ guide and related documentation ( https://zenodo.org/records/15808136 )”
A documentation object (users' guide and related documentation) is named as being deposited alongside the data. [majority verdict 'yes' (3/5 passes agreed)]
RDA-R1-01M — '(Meta)data are richly described with a plurality of accurate and relevant attribu · FsF-R1-01MD — F-UJI: 'Metadata specifies the content of the data' · NIH DMS Policy Element 3 (NOT-OD-21-014) — Standards (documentation and metadata to accompany t
Calibrated FAIR score — a parallel quality metric, independent of the DataRank citation score. See the full evaluation →
Base Score Contribution
0.524
From this paper's citation signal
Citation Network Contribution
0.0657
From 4 citing papers with measurable signal
Ranked by each citer's contribution to N(p) — log1p(Cq) divided by its reference count — out of 29 citers.
National Institutes of Health
Grant: U24HG012198
National Institutes of Health
Grant: U24HG012198-02S1
National Institutes of Health
Grant: U24HG011851
Open Targets
European Bioinformatics Institute
Connected Minds Prototyping
FWCI
13.91
Citation Percentile
1.0%
Citation Trend
Fields of Study
MeSH Terms
Keywords