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Structural integrity and side-chain interaction at the loop region of the bridge helix modulate Cas9 substrate discrimination

Nucleic Acids Research(2025)10.1093/nar/gkaf557Source: DataRank Database

Structural integrity and side-chain interaction at the loop region of the bridge helix modulate Cas9 substrate discrimination is a research paper published in Nucleic Acids Research (2025). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (9 grants)Impact (FWCI 1.25)OA: goldTopics (27)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Sydney Snead,Chhandosee Ganguly,Kesavan Babu ORCID,Yue Li ORCID,Venkatesan Kathiresan ORCID

Live enrichment

PubMed:40613714 PMC:PMC12231601 OpenAlex:https://openalex.org/W4412034048

National Science Foundation

Grant: MCB-1716744

National Science Foundation

Grant: MCB-1818107

National Science Foundation

Grant: MCB-1716423

National Science Foundation

Grant: MCB-2424888

National Institutes of Health

Grant: R35-GM145341

NIGMS NIH HHS

Grant: P30 GM145423

NIGMS NIH HHS

Grant: R35 GM145341

NIGMS NIH HHS

Grant: R24 GM146107

Arnold and Mabel Beckman Foundation

FWCI

1.25

Citation Percentile

0.8%

Citation Trend

2026

goldLicense: cc-by-nc

journalhttps://academic.oup.com/nar/article-pdf/53/12/gkaf557/63669705/gkaf557.pdf

publisherhttps://academic.oup.com/nar/article-pdf/53/12/gkaf557/63669705/gkaf557.pdf

journalhttps://doi.org/10.1093/nar/gkaf557

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40613714

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12231601

Fields of Study

CRISPR and Genetic EngineeringRNA and protein synthesis mechanismsAdvanced biosensing and bioanalysis techniques

MeSH Terms

CRISPR-Associated Protein 9RNA, Guide, CRISPR-Cas SystemsDNAModels, MolecularProtein BindingProtein ConformationSubstrate SpecificityDNA CleavageCRISPR-Cas Systems

Keywords

Cas9BiologyCRISPRGuide RNADNANucleaseBiophysicsRNAHelix (gastropod)Point mutationMutantCell biologyGeneticsComputational biologyGene

Sustainable Development Goals

SDG 0: Reduced inequalities

Structural integrity and side-chain interaction at the loop region of the bridge helix modulate Cas9 substrate discrimination

FAIR Checklist

Authors (10)

Funding (9 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)