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A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin

Nucleic Acids Research(2025)10.1093/nar/gkaf627Source: DataRank Database

A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin is a research paper published in Nucleic Acids Research (2025). On theSindex it has a DataRank of 0. It has been cited 6 times.

N/A

0DataRank · unranked

Scored on demand from live citation data

Open Access6 citations

Cite:

Linked data & code

pxd doi

DataRank reads this dataset's downstream impact straight off the citation graph — no black box, no proprietary weighting. How is this computed?

›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (13 grants)Impact (FWCI 2.94)OA: goldTopics (76)IDs (PubMed, PMC, OpenAlex)Annotations (2)SDGs (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Alla Polotskaia,Gu Xiao ORCID,Pamella Leybengrub,Rusia Lee ORCID,Weigang Qiu ORCID

Live enrichment

PubMed:40626562 PMC:PMC12235508 OpenAlex:https://openalex.org/W4412110875

The Breast Cancer Research Foundation

Grant: BCRF-20–011

The Breast Cancer Research Foundation

Grant: BCRF-21–011

The Breast Cancer Research Foundation

Grant: BCRF-22–011

The Breast Cancer Research Foundation

Grant: BCRF-23–011

The Breast Cancer Research Foundation

Grant: BCRF-24-011

National Institutes of Health

Grant: R01CA239603

National Institutes of Health

Grant: U54 CA221704

The Breast Cancer Research Foundation

Grant: BCRF-23-011

The Breast Cancer Research Foundation

Grant: BCRF-20-011

The Breast Cancer Research Foundation

Grant: BCRF-21-011

The Breast Cancer Research Foundation

Grant: BCRF-22-011

National Institutes of Health

Grant: 1R01CA239603-01A1

The Role of the Mutant p53-PARP-MCM Pathway in Triple Negative Breast Cancer

National Institutes of Health

Grant: 5U54CA221704-04

(2/2) TUFCCC/HC Regional Comprehensive Cancer Health Disparity Partnership

FWCI

2.94

Citation Percentile

0.9%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1093/nar/gkaf627

publisherhttps://doi.org/10.1093/nar/gkaf627

publisherhttps://academic.oup.com/nar/article-pdf/53/13/gkaf627/63699596/gkaf627.pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40626562

repositoryhttps://www.ncbi.nlm.nih.gov/pmc/articles/12235508

Fields of Study

Cancer-related Molecular PathwaysDNA Repair MechanismsEpigenetics and DNA Methylation03 medical and health sciences0302 clinical medicineHumansTumor Suppressor p53-Binding Protein 1Proto-Oncogene Proteins c-mdm2ChromatinDNA RepairTumor Suppressor Protein p53Cell Cycle ProteinsCell Line, TumorProto-Oncogene ProteinsNuclear ProteinsAdaptor Proteins, Signal TransducingTrans-ActivatorsMutationBreast NeoplasmsIntracellular Signaling Peptides and ProteinsPiperazinesFemaleImidazolesProtein Binding

MeSH Terms

Tumor Suppressor p53-Binding Protein 1Breast NeoplasmsChromatinDNA RepairFemaleHumansImidazolesMutationNuclear ProteinsPiperazinesProtein BindingProto-Oncogene ProteinsTrans-ActivatorsTumor Suppressor Protein p53Cell Cycle ProteinsCell Line, TumorIntracellular Signaling Peptides and ProteinsAdaptor Proteins, Signal TransducingProto-Oncogene Proteins c-mdm2

Keywords

BiologyMDMXChromatinMdm2DNA damageDNA repairCell cycleCancer researchCell biologyMolecular biologyCancerDNACell cultureGeneticsIntracellular Signaling Peptides and ProteinsImidazolesNuclear ProteinsProto-Oncogene Proteins c-mdm2Cell Cycle ProteinsBreast NeoplasmsGenome Integrity, Repair and ReplicationArticlePiperazinesCell Line, TumorProto-Oncogene ProteinsMutationTrans-ActivatorsHumansFemaleTumor Suppressor Protein p53Tumor Suppressor p53-Binding Protein 1Adaptor Proteins, Signal TransducingProtein Binding

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being

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Research Square(2023)

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