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Directed evolution expands CRISPR–Cas12a genome-editing capacity

Nucleic Acids Research(2025)10.1093/nar/gkaf649Source: DataRank Database

Directed evolution expands CRISPR–Cas12a genome-editing capacity is a research paper published in Nucleic Acids Research (2025). On theSindex it has a DataRank of 0. It has been cited 15 times.

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Open Access15 citations

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Enrichment:Funding (30 grants)Impact (FWCI 6.54)OA: goldTopics (30)IDs (PubMed, PMC, OpenAlex)Annotations (1)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (9)

Kai Chen ORCID,Honglue Shi ORCID,Kevin Wasko ORCID,Isabel Esain-Garcia ORCID,Marena Trinidad ORCID

Live enrichment

PubMed:40671523 PMC:PMC12266133 OpenAlex:https://openalex.org/W4412487705

NIH

Grant: U01AI142817

NIAID

Grant: U19AI171110

NIAID

Grant: U54AI170792

NIAID

Grant: U19AI135990

NIAID

Grant: UH3AI150552

NIAID

Grant: U19NS132303

NHLBI

Grant: R21HL173710

NSF

Grant: 2334028

DOE

Grant: DE-AC02-05CH11231

DOE

Grant: 2553571

DOE

Grant: B656358

Lawrence Livermore National Laboratory

Grant: 24180

Innovative Genomics Institute

Koret-Berkeley-TAU

Life Sciences Research Foundation

Howard Hughes Medical Institute

The Jane Coffin Childs Fund for Medical Research

Rett Syndrome Research Trust

CB-Hampton University Summer Program

Mr Li Ka Shing

Emerson Collective

Life Sciences Research Foundation

Mr Li Ka Shing

Howard Hughes Medical Institute

Emerson Collective

Innovative Genomics Institute

CB-Hampton University Summer Program

Rett Syndrome Research Trust

The Jane Coffin Childs Fund for Medical Research

Koret-Berkeley-TAU

FWCI

6.54

Citation Percentile

1.0%

Citation Trend

2025

2026

goldLicense: cc-by

journalhttps://doi.org/10.1093/nar/gkaf649

publisherhttps://doi.org/10.1093/nar/gkaf649

publisherhttps://academic.oup.com/nar/article-pdf/53/13/gkaf649/63778750/gkaf649.pdf

repositoryhttps://pubmed.ncbi.nlm.nih.gov/40671523

repositoryhttps://escholarship.org/uc/item/7n89c79w

Fields of Study

CRISPR and Genetic EngineeringRNA and protein synthesis mechanismsInsect symbiosis and bacterial influencesCRISPR-Cas SystemsGene EditingHumansCRISPR-Associated ProteinsDirected Molecular EvolutionEndodeoxyribonucleasesBacterial ProteinsGenome, Human

MeSH Terms

Gene EditingBacterial ProteinsEndodeoxyribonucleasesHumansGenome, HumanDirected Molecular EvolutionCRISPR-Cas SystemsCRISPR-Associated Proteins

Keywords

BiologyCRISPRGenome editingGenome engineeringGenomeComputational biologyGeneticsGeneHuman genomeDNACas9

Sustainable Development Goals

SDG 0: Zero hunger

Directed evolution expands CRISPR–Cas12a genome-editing capacity

FAIR Checklist

Authors (9)

Funding (30 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)