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A Targeted Metabolomics-Based Assay Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Identifies Structural and Functional Cardiotoxicity Potential

Toxicological Sciences(2020)10.1093/toxsci/kfaa015Source: DataRank Database

A Targeted Metabolomics-Based Assay Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Identifies Structural and Functional Cardiotoxicity Potential is a research paper published in Toxicological Sciences (2020). On theSindex it has a DataRank of 0. It has been cited 36 times.

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Open Access36 citations

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Enrichment:Funding (3 grants)OA: hybridTopics (40)IDs (PubMed, PMC)Annotations (1)SDGs (1)

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Authors (6)

Alan M. Smith ORCID,Vitalina Gryshkova ORCID,Elizabeth L.R. Donley,Jean‐Pierre Valentin ORCID,Robert E. Burrier

Live enrichment

PubMed:32040181 PMC:PMC7098380

National Institutes of Health

Grant: R44GM100640

National Institutes of Health

Grant: 2R44GM100640-02

Identification of Biomarkers of Cardiotoxicity using Metabolomics of Human Pluripotent Stem Cell-Derived Cardiomyocytes

National Institute of General Medical Sciences

hybridLicense: OUP Standard Publication Reuse

publisherhttp://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfaa015/32815800/kfaa015.pdf

publisherhttp://academic.oup.com/toxsci/article-pdf/174/2/218/32966249/kfaa015.pdf

https://doi.org/10.1093/toxsci/kfaa015

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098380

https://pubmed.ncbi.nlm.nih.gov/32040181

Fields of Study

0301 basic medicine03 medical and health sciences

MeSH Terms

Cell LineMyocytes, CardiacHumansHeart DiseasesXenobioticsChromatography, LiquidRisk AssessmentMolecular StructureStructure-Activity RelationshipDose-Response Relationship, DrugTandem Mass SpectrometryMetabolomicsMetabolomeDrug DiscoveryInduced Pluripotent Stem CellsCardiotoxicityBiomarkers

Keywords

MetabolitesIn vitroCardiotoxicityDrug Discovery And DevelopmentHipsc-cmDose-Response Relationship, DrugHeart DiseasesMolecular StructureInduced Pluripotent Stem CellsRisk AssessmentCell LineXenobioticsStructure-Activity RelationshipTandem Mass SpectrometryDrug DiscoveryMetabolomeHumansMetabolomicsMyocytes, CardiacBiomarkersChromatography, Liquid

Sustainable Development Goals

SDG 3: 3. Good health