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Circular RNA hsa_circ_0099188 regulates inducible nitric oxide synthase and chemokine transcription in macrophages by targeting the hsa-miR-381-3p/PPP3CA and hsa-miR-381-3p/KLF4 pathways in response to 4,4′-methylene diphenyl diisocyanate-glutathione conjugate exposure

Toxicological Sciences(2025)10.1093/toxsci/kfaf114Source: DataRank Database

Circular RNA hsa_circ_0099188 regulates inducible nitric oxide synthase and chemokine transcription in macrophages by targeting the hsa-miR-381-3p/PPP3CA and hsa-miR-381-3p/KLF4 pathways in response to 4,4′-methylene diphenyl diisocyanate-glutathione conjugate exposure is a research paper published in Toxicological Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 2 times.

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0DataRank · unranked

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Open Access2 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (3 grants)Impact (FWCI 0.97)OA: greenTopics (52)IDs (PubMed, PMC, OpenAlex)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (3)

Brandon F. Law ORCID,Justin M. Hettick ORCID,Chen‐Chung Lin ORCID

Live enrichment

PubMed:40796177 PMC:PMC12406230 OpenAlex:https://openalex.org/W4413114130

National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention

Grant: CAN#19390BN8

National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention

Grant: #39390KK5

Intramural CDC HHS

Grant: CC999999

FWCI

0.97

Citation Percentile

0.8%

Citation Trend

2026

greenLicense: public-domain

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12406230/

publisherhttps://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfaf114/64014934/kfaf114.pdf

publisherhttps://academic.oup.com/toxsci/article-pdf/208/1/122/64014934/kfaf114.pdf

journalhttps://doi.org/10.1093/toxsci/kfaf114

Fields of Study

Circular RNAs in diseasesMicroRNA in disease regulationGenomics, phytochemicals, and oxidative stressMicroRNAsHumansKruppel-Like Factor 4Nitric Oxide Synthase Type IIRNA, CircularMacrophagesIsocyanatesChemokinesGlutathioneAnimalsMiceTranscription, GeneticKruppel-Like Transcription FactorsBenzhydryl Compounds

MeSH Terms

RNA, CircularKruppel-Like Factor 4AnimalsBenzhydryl CompoundsGlutathioneHumansMacrophagesTranscription, GeneticIsocyanatesChemokinesMicroRNAsMiceKruppel-Like Transcription FactorsNitric Oxide Synthase Type II

Keywords

ChemistryNitric oxide synthaseTranscription (linguistics)ChemokineCircular RNACell biologyCCL21Molecular biologyNitric oxideRNABiologyGeneBiochemistryChemokine receptorReceptorKrüppel-like Factor 4 (Klf4)Circular Rnas (Circrnas)Occupational Asthma (Oa)4,4′-Methylene Diphenyl Diisocyanate (Mdi)Hsa-mir-381-3pProtein Phosphatase 3 Catalytic Subunit Alpha (Ppp3ca)