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Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice

Toxicological Sciences(2025)10.1093/toxsci/kfaf151Source: DataRank Database

Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice is a research paper published in Toxicological Sciences (2025). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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Enrichment:Funding (5 grants)Impact (FWCI 0.90)OA: greenTopics (30)IDs (PubMed, PMC, OpenAlex)Annotations (2)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (8)

Gillian Williams,Ranjan Mukherjee ORCID,Anne Orr,Jiajun Liu ORCID,Silvia Liu ORCID

Live enrichment

PubMed:41148051 PMC:PMC12614225 OpenAlex:https://openalex.org/W4415620313

National Institutes of Health

Grant: R01 DK135566

National Institutes of Health

Grant: R01 DK122990

Pittsburgh Liver Research Center (PLRC) National Institutes of Health

Grant: P30 DK120531

National Institutes of Health

Grant: S10OD028483

University of Pittsburgh Center

FWCI

0.90

Citation Percentile

0.8%

Citation Trend

2026

greenLicense: https://academic.oup.com/pages/standard-publication-reuse-rights

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12614225/pdf/nihms-2121690.pdf

publisherhttps://academic.oup.com/toxsci/advance-article-pdf/doi/10.1093/toxsci/kfaf151/65004493/kfaf151.pdf

publisherhttps://academic.oup.com/toxsci/article-pdf/209/1/kfaf151/65004493/kfaf151.pdf

repositoryhttps://pmc.ncbi.nlm.nih.gov/articles/PMC12614225/

Fields of Study

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathologyCancer, Stress, Anesthesia, and Immune Response

MeSH Terms

AcetaminophenAnimalsLiverLiver RegenerationMaleMice, Inbred C57BLGene DeletionMice, KnockoutHepatocytesMiceChemical and Drug Induced Liver InjuryErbB Receptors

Keywords

Liver injuryEpidermal growth factor receptorDownregulation and upregulationHepatocyteGlutathioneTranscription factorAutophagyProgrammed cell deathReceptorGenetically modified mouseLiver regenerationAcute liver failureJNKGclcTfeb

Hepatocyte-specific epidermal growth factor receptor (EGFR) deletion attenuates acetaminophen-induced liver injury in mice

FAIR Checklist

Authors (8)

Funding (5 grants)

Impact

Open Access

Topics

Annotations (Europe PMC)