Alphaviruses: Host pathogenesis, immune response, and vaccine & treatment updates is a research paper published in Journal of General Virology (2021). On theSindex it has a DataRank of 0.952. It has been cited 23 times, with 23 citing works in its 1-hop citation network.
Human pathogens belonging to theAlphavirusgenus, in theTogaviridaefamily, are transmitted primarily by mosquitoes. The signs and symptoms associated with these viruses include fever and polyarthralgia, defined as joint pain and inflammation, as well as encephalitis. In the last decade, our understanding of the interactions between members of the alphavirus genus and the human host has increased due to the re-appearance of the chikungunya virus (CHIKV) in Asia and Europe, as well as its emergence in the Americas. Alphaviruses affect host immunity through cytokines and the interferon response. Understanding alphavirus interactions with both the innate immune system as well as the various cells in the adaptive immune systems is critical to developing effective therapeutics. In this review, we summarize the latest research on alphavirus-host cell interactions, underlying infection mechanisms, and possible treatments.
FAIR checklist signals are shown for context only and do not affect DataRank scoring.
Base Score Contribution
0.477
From this paper's citation signal
Citation Network Contribution
0.475
From 20 citing papers with measurable signal
Ranked by citation count — the same ordering the engine uses when summing log1p(Cq) over citers.
DataRank blends this paper's own citation count with the influence of the papers that cite it. Here, roughly 50% comes from its base citations and 50% from the citation network (20 citing papers contributed measurable signal).
Citers are pulled from OpenAlex sorted by cited_by_count:descand capped per paper, so when the cap binds we keep the highest-signal references and the score is reproducible across reruns.
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