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Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.01.20.913012Source: DataRank Database

Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: greenTopics (36)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (19)

Susmita Khamrui,Hui Wang ORCID,Chalada Suebsuwong ORCID,Natalia S. Nemeria,Khoi Huynh

Live enrichment

PubMed:23304386 OpenAlex:https://openalex.org/W3002383060

National Institutes of Health

Grant: 3P41GM111244-03S1

Life Science and Biomedical technology Research center at NSLS-II LSBR

National Institutes of Health

Grant: 5R21HD088775-02

Novel Treatment Options for Glutaric Aciduria

National Institutes of Health

Grant: 5R03HD092878-02

Genetic validation of DHTKD1 as a therapeutic target for the treatment of Glutaric Aciduria type 1

National Institutes of Health

Grant: 5UL1TR001433-02

MSHS Translational Science Hub

National Institutes of Health

Grant: 5R35GM124838-04

Chemical and structural tools to study energy homeostasis pathways in cancer and diabetes

greenLicense: STM Policy #29

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/01/21/2020.01.20.913012.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.01.20.913012

repositoryhttps://doi.org/10.1101/2020.01.20.913012

repositoryhttps://escholarship.org/uc/item/5dj5p5mg

Fields of Study

Biochemical Acid Research StudiesMetabolism and Genetic DisordersAlcoholism and Thiamine Deficiency0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

EnzymeBiochemistryChemistryCofactorMissense mutationProtein structureTransferaseBiologyMutationGeneCrystallographyMolecular StructureCircular DichroismOrganic ChemistryNeurosciencesMutation, MissenseBiological SciencesCrystallography, X-RayOrphan DrugRare DiseasesCharcot-Marie-Tooth DiseaseChemical SciencesGeneticsX-Ray2.1 Biological and endogenous factorsHumansKetoglutarate Dehydrogenase ComplexAetiologyMissenseThiamine Pyrophosphate

Sustainable Development Goals

SDG 3: 3. Good health