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An unbiased drug screen for seizure suppressors in Dup15q syndrome reveals 5HT 1A and dopamine pathway activation as potential therapies

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.02.18.954560Source: DataRank Database

An unbiased drug screen for seizure suppressors in Dup15q syndrome reveals 5HT 1A and dopamine pathway activation as potential therapies is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0.

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (2 grants)OA: greenTopics (19)IDs (PubMed, OpenAlex)SDGs (2)

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Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (6)

Jungsoo Han ORCID,Kevin A. Hope ORCID,Tracy L. Peters ORCID,Glen E. Palmer ORCID,Lawrence T. Reiter ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W3008900062

National Institutes of Health

Grant: 1R21HD091541-01

An in vivo chemical screen for seizure suppression in Duplication 15q syndrome.

National Institutes of Health

Grant: 3P40OD018537-04S1

Bloomington Drosophila Stock Center at Indiana University

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/02/19/2020.02.18.954560.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.02.18.954560

repositoryhttps://doi.org/10.1101/2020.02.18.954560

https://europepmc.org/articles/pmc7554174?pdf=render

Fields of Study

Genetics and Neurodevelopmental DisordersCRISPR and Genetic EngineeringProtein Degradation and Inhibitors0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

DopamineEpilepsyDopaminergicSerotonergicDopaminergic pathwaysSerotoninNeuroscience5-HT receptorPharmacologyMedicineBiologyReceptorInternal medicine

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being