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GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.02.28.970228Source: DataRank Database

GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Enrichment:Funding (12 grants)OA: greenTopics (24)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (27)

Barbara Scott Nelson ORCID,Lin Lin ORCID,Emily L. Yarosz ORCID,Christopher J. Halbrook ORCID,Samuel A. Kerk ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W3008076852

National Institutes of Health

Grant: 1R01CA198074-01

Dosage-Dependent Hedgehog Signaling in Pancreatic Cancer

National Institutes of Health

Grant: 1T32CA009676-01A1

CANCER BIOLOGY TRAINING PROGRAM

National Institutes of Health

Grant: 2T32DK094775-11A1

Training in Basic and Translational Digestive Sciences

National Institutes of Health

Grant: 5R01CA148828-09

The role of HIF2alpha in colon carcinogenesis

National Institutes of Health

Grant: 5T32DK094775-04

Training in Basic and Translational Digestive Sciences

National Institutes of Health

Grant: 4U01CA224145-02

Interrupting Cellular Crosstalk in the Immunosuppressive Microenvironment of Pancreas Cancer

National Institutes of Health

Grant: 5R01CA215607-08

Targeting cysteine import to induce ferroptotic cell death in pancreatic cancer

National Institutes of Health

Grant: 5R01CA215607-04

Targeting cysteine import to induce ferroptotic cell death in pancreatic cancer

National Institutes of Health

Grant: 5R01CA151588-08

Mechanisms of Pancreatic Inflammation, Tissue Repair and Carcinogenesis

National Institutes of Health

Grant: 3P30CA046592-31S7

Cancer Center Support Grant 2018-2023

National Institutes of Health

Grant: 1R01DK095201-01

Control of iron absorption by intestinal HIF2 in iron and hematological disorders

National Institutes of Health

Grant: 3R01DK095201-11S1

Control of iron absorption by intestinal HIF2 in iron and hematological disorders

greenLicense: cc-by-nc-nd

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/02/29/2020.02.28.970228.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.02.28.970228

repositoryhttps://doi.org/10.1101/2020.02.28.970228

https://dx.doi.org/10.1101/2020.02.28.970228

Fields of Study

Ferroptosis and cancer prognosisEpigenetics and DNA MethylationAutophagy in Disease and Therapy0301 basic medicine03 medical and health sciences

Keywords

GlutathioneProgrammed cell deathCancer cellOxidative stressAutophagyCell biologyChemistryGene knockdownApoptosisCytosolOxidative phosphorylationGrowth inhibitionCell culturePancreatic cancerBiochemistryBiologyCancerEnzymeGenetics

Sustainable Development Goals

SDG 3: 3. Good health