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Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.12.090688Source: DataRank Database

Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0.226. It has been cited 3 times, with 1 citing works in its 1-hop citation network.

N/A

0.226DataRank · unranked

Scored on demand from live citation data

Open Access3 citations · 1 citing works in its network

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

Pipeline:MetadataData-paper checkEnrichmentCitation networkScoring

Enrichment:Funding (4 grants)OA: greenTopics (54)IDs (PubMed, OpenAlex)SDGs (1)

FAIR Checklist

Context only (not used in score)

Findable (1/2)

Has DOI

Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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DataRank Breakdown

Base Score 92%Citation Network 8%

Base Score Contribution

0.208

From this paper's citation signal

Citation Network Contribution

0.0179

From 1 citing papers with measurable signal

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Top 1 citer driving the network score

Ranked by each citer's contribution to N(p) — log1p(C_q) divided by its reference count — out of 1 citer.

Shared early molecular mechanisms revealed in P301S and 5xFAD Alzheimer’s disease mouse models
Translational Psychiatry20257 citations99 referencesContributes 0.021

Authors (13)

William T. Ralvenius ORCID,Alexi Nott ORCID,L. Ashley Watson,Felicia H. Rodriguez ORCID,Leyla Anne Akay ORCID

Live enrichment

PubMed:19767382 OpenAlex:https://openalex.org/W3024485859

National Institutes of Health

Grant: 5T32GM008334-24

Interdepartmental Biotechnology Training Program

National Institutes of Health

Grant: 1U54CA210180-01

MIT/Mayo Physical Sciences Center for Drug Distribution and Efficacy in Brain Tumors

National Institutes of Health

Grant: 5R37NS051874-23

The Cdk5/35 Kinase

National Institutes of Health

Grant: 1RF1AG054321-01

Demystifying Microglia in Aging and Alzheimer's Disease

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/05/14/2020.05.12.090688.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.05.12.090688

repositoryhttps://doi.org/10.1101/2020.05.12.090688

repositoryhttps://hdl.handle.net/1721.1/130482

Fields of Study

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsGlycosylation and Glycoproteins Research0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

SIGLECNeurodegenerationPhosphoproteomicsMicrogliaEndocytic cycleCell biologyDownregulation and upregulationBiologyProinflammatory cytokineInflammationNeurosciencePhosphorylationImmunologyImmune systemReceptorMedicineBiochemistryDiseaseProtein phosphorylationPathologyEndocytosisProtein kinase AProteomicsMedicine (General)ProteomeQH301-705.5Mice, TransgenicAntibodiesCell LineInterferon-gammaR5-920PhagocytosisAlzheimer DiseaseAnimalsHumansAmino Acid SequenceBiology (General)PhosphotyrosineSialic Acid Binding Immunoglobulin-like LectinsSiglec‐8Cell DeathArticlesAlzheimer's diseasePhosphoproteinsSiglec‐FNerve DegenerationPeptidesSignal Transduction

Sustainable Development Goals

SDG 0: Good health and well-being