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Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.05.21.107425Source: DataRank Database

Repeat length increases disease penetrance and severity in C9orf72 ALS/FTD BAC transgenic mice is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0. It has been cited 1 time.

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Open Access1 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (1 grants)OA: greenTopics (34)IDs (PubMed, OpenAlex)SDGs (2)

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Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (10)

Lien Nguyen ORCID,Hailey Olafson,Marina M. Scotti,Lauren A. Laboissonniere ORCID,Jared Richardson

Live enrichment

PubMed:26207759 OpenAlex:https://openalex.org/W3027017497

National Institutes of Health

Grant: 5R01NS098819-04

Molecular Characterization of ALS/FTD in a novel C9orf72 BAC mouse model.

greenLicense: OUP Standard Publication Reuse

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/05/22/2020.05.21.107425.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.05.21.107425

repositoryhttps://doi.org/10.1101/2020.05.21.107425

https://doi.org/10.1093/hmg/ddaa279

Fields of Study

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative DiseasesPrion Diseases and Protein Misfolding0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

C9orf72PenetranceTransgeneBiologyGenetically modified mouseTrinucleotide repeat expansionPhenotypeRNA splicingDiseaseGeneticsFrontotemporal dementiaTranscriptomeMutationGeneRNAMedicineGene expressionPathologyDementiaDNA Repeat ExpansionC9orf72 ProteinAmyotrophic Lateral SclerosisMice, TransgenicAlternative SplicingDisease Models, AnimalMiceAnimalsHumans

Sustainable Development Goals

SDG 3: 3. Good healthSDG 0: Good health and well-being