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The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.05.238394Source: DataRank Database

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0. It has been cited 7 times.

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Open Access7 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: goldTopics (41)IDs (PubMed)Annotations (1)SDGs (1)

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Context only (not used in score)

Findable (1/2)

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Accessible (1/2)

Open Access

Interoperable (0/2)

Reusable (0/3)

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Authors (23)

Rachel A. Sattler,Elke Mühlberger ORCID,Jason D. Graci ORCID,Liangxian Cao ORCID,Marla Weetall ORCID

Live enrichment

PubMed:32793904

National Institutes of Health

Grant: 3UL1TR001430-05A1S2

Boston University Clinical and Translational Science Institute

National Institutes of Health

Grant: 5R35GM122468-05

Genetic nonsense and its consequences

National Institutes of Health

Grant: 5TL1TR001440-08

NRSA Training Core

National Institutes of Health

Grant: 1R01AI148784-01

Insight into the Ebola virus glycoprotein fusion mechanism gleaned from the 2013-2016 epidemic GP-A82V variant

National Institutes of Health

Grant: 5R37AI147868-05

The HUSH complex in HIV-1 latency

goldLicense: Elsevier TDM

Europe_PMChttps://europepmc.org/article/PPR/PPR197190

Europe_PMChttps://europepmc.org/api/fulltextRepo?pprId=PPR197190&type=FILE&fileName=EMS92640-pdf.pdf&mimeType=application/pdf

https://doi.org/10.1016/j.virusres.2020.198246

https://doi.org/10.1101/2020.08.05.238394

https://pubmed.ncbi.nlm.nih.gov/33249060

Fields of Study

0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

Cancer ResearchOxidoreductases Acting on CH-CH Group DonorsCarbazolesDihydroorotate DehydrogenaseInfectious DiseaseCytokine stormVirus ReplicationMicrobiologyAntiviral AgentsArticleVirologyEnzymes and CoenzymesChlorocebus aethiopsAnimalsHumansAntiviralAmino AcidsCytokineMolecular BiologyVero CellsInflammationSARS-CoV-2PTC299and ProteinsCOVID-19DHODHImmunoprophylaxis and TherapyCOVID-19 Drug TreatmentCoronavirusImmunology of Infectious DiseaseInfectious DiseasesVirus DiseasesCytokinesImmunotherapyCarbamatesPeptidesCytokine Release SyndromeHeLa Cells

Sustainable Development Goals

SDG 3: 3. Good health

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

FAIR Checklist

Authors (23)

Funding (5 grants)

Open Access

Topics

Annotations (Europe PMC)