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Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.19.258236Source: DataRank Database

Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Male and Female Mice is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0.

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Enrichment:Funding (2 grants)OA: greenTopics (31)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (6)

Su-Youne Chang ORCID,Jarred J. Nesbitt,Nicholas P. Pichurin ORCID,Mark Ostroot ORCID,Eugenia Trushina ORCID

Live enrichment

PubMed:21097893 OpenAlex:https://openalex.org/W3075190902

National Institutes of Health

Grant: 4RF1AG055549-03

Mitochondrial Complex I as a Target for Neuroprotection in AD

National Institutes of Health

Grant: 1RF1AG062135-01

AMP-Kinase as a target for neuroprotection in AD

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/08/20/2020.08.19.258236.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.08.19.258236

repositoryhttps://doi.org/10.1101/2020.08.19.258236

https://dx.doi.org/10.1101/2020.08.19.258236

Fields of Study

Alzheimer's disease research and treatmentsMitochondrial Function and PathologyNeuroscience and Neuropharmacology Research0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

Morris water navigation taskNeuroprotectionLong-term potentiationGSK-3MitochondrionInternal medicineEndocrinologyHippocampusEnergy homeostasisCyclin-dependent kinase 5Synaptic plasticityHomeostasisTau proteinGlycogen synthaseNeuroscienceBiologyChemistryMedicineKinaseGlycogenAlzheimer's diseaseProtein kinase ACell biologyReceptorDisease

Sustainable Development Goals

SDG 0: Affordable and clean energy