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Developmental stage-specific changes in protein synthesis differentially sensitize hematopoietic stem cells and erythroid progenitors to impaired ribosome biogenesis

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.08.22.262816Source: DataRank Database

Developmental stage-specific changes in protein synthesis differentially sensitize hematopoietic stem cells and erythroid progenitors to impaired ribosome biogenesis is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0. It has been cited 2 times.

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Open Access2 citations

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datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (6 grants)OA: greenTopics (61)IDs (PubMed, OpenAlex)SDGs (1)

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Authors (2)

Robert Signer ORCID,Jeffrey A. Magee ORCID

Live enrichment

PubMed:23304386 OpenAlex:https://openalex.org/W3080360126

National Institutes of Health

Grant: 1S10RR027366-01A1

FACSAria II Cell Sorter

National Institutes of Health

Grant: 1R01DK124775-01

Ex vivo hematopoietic stem cell growth mediated by the heat shock response

National Institutes of Health

Grant: 5R01HL136504-02

TEMPORAL CHANGES IN MECHANISMS OF HSC SELF-RENEWAL AND MYELOID LEUKEMOGENESIS

National Institutes of Health

Grant: 1R01HL152180-01

The role of Kmt2c/MLL3 in hematopoietic stem cell self-renewal, commitment and exhaustion

National Institutes of Health

Grant: 1R01DK116951-01

Protein Homeostasis in Hematopoietic Stem Cells

National Institutes of Health

Grant: 3P30CA023100-25S4

Specialized Cancer Center Support Grant

greenLicense: CC BY NC ND

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/08/23/2020.08.22.262816.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.08.22.262816

repositoryhttps://doi.org/10.1101/2020.08.22.262816

repositoryhttps://digitalcommons.wustl.edu/open_access_pubs/11199

Fields of Study

Erythrocyte Function and PathophysiologyRNA modifications and cancerBlood disorders and treatments0301 basic medicine03 medical and health sciences0303 health sciences

Keywords

BiologyRibosome biogenesisProgenitor cellHaematopoiesisCell biologyStem cellErythropoiesisProtein biosynthesisRibosomal proteinRibosomeBiogenesisMolecular biologyGeneticsInternal medicineRNAMedicineAnemiaRibosomal Proteins570Erythrocytesprotein synthesis1.1 Normal biological development and functioningClinical Sciences610translationBone Marrow CellsMice, TransgenicribosomopathyRegenerative MedicineInbred C57BLTransgenicFetal DevelopmentMiceFetusStem Cell Research - Nonembryonic - HumanReportAnimalsproteostasiserythroidHematopoietic Stem Cell TransplantationprogenitorCell DifferentiationHematologyBiological SciencesStem Cell ResearchHematopoietic Stem CellshematopoiesisMice, Inbred C57BLBloodLiverBiochemistry and cell biologyMutationStem Cell Research - Nonembryonic - Non-Humanhematopoietic stem cellRibosomes

Sustainable Development Goals

SDG 0: Good health and well-being