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Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors

bioRxiv (Cold Spring Harbor Laboratory)(2020)10.1101/2020.09.22.308700Source: DataRank Database

Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors is a research paper published in bioRxiv (Cold Spring Harbor Laboratory) (2020). On theSindex it has a DataRank of 0. It has been cited 3 times.

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Open Access3 citations

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›Methodology & internals

datarank_citation_only_1hop_v6· scope data_onlyMethodology

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Enrichment:Funding (5 grants)OA: greenTopics (33)IDs (PubMed, OpenAlex)

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Authors (11)

Keith J. Mickolajczyk ORCID,Jonathan B. Steinman ORCID,L. Urnavicius,Nan Chen ORCID,Yasuhiro Hirata

Live enrichment

PubMed:19767382 OpenAlex:https://openalex.org/W3088088934

National Institutes of Health

Grant: 5R35GM130234-03

Chemical Biology of Cell Division

National Institutes of Health

Grant: 1S10RR027037-01

Crystallization Robot for the Structural Biology Resource Center at Rockefeller

National Institutes of Health

Grant: 5R00GM112982-05

Structure and mechanism of cytoplasmic and axonemal dyneins

National Institutes of Health

Grant: 5K00CA223018-05

A biophysical approach to elucidating the molecular mechanisms of mitotic inhibitor targets

National Institutes of Health

Grant: 5R01GM098579-02

Studying chromosome function using chemical biology

greenLicense: https://www.biorxiv.org/about/FAQ#license

repositoryhttps://www.biorxiv.org/content/biorxiv/early/2020/09/22/2020.09.22.308700.full.pdf

publisherhttps://syndication.highwire.org/content/doi/10.1101/2020.09.22.308700

repositoryhttps://doi.org/10.1101/2020.09.22.308700

https://doi.org/10.1016/j.chembiol.2021.04.024

Fields of Study

Microtubule and mitosis dynamicsProtist diversity and phylogenyPhotosynthetic Processes and Mechanisms0301 basic medicine0303 health sciences03 medical and health sciences

Keywords

DyneinAllosteric regulationDynactinATPaseMicrotubuleMotor proteinMutagenesisBiologyCell biologySmall moleculeEnzymeChemistryBiochemistryMutantGeneBinding SitesSaccharomyces cerevisiae ProteinsCryoelectron MicroscopyDyneinsSaccharomyces cerevisiaeMolecular Docking SimulationSmall Molecule LibrariesCatalytic DomainMutagenesis, Site-DirectedHumansPyrazolesProtein Binding